Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone.

Infection and Immunity
T Van der Poll, S F Lowry

Abstract

To determine the effect of epinephrine and hydrocortisone on lipopolysaccharide (LPS)-induced interleukin 8 (IL-8) production, human whole blood was stimulated with LPS in the presence or absence of these stress hormones. Epinephrine caused a dose-dependent increase in LPS-induced IL-8 production, which was mediated exclusively via beta-adrenergic receptors, as reflected by the facts that beta (but not alpha) receptor blockade reversed the epinephrine effect and beta (but not alpha) receptor stimulation reproduced the epinephrine effect. Further, elevating cellular cyclic AMP (cAMP) concentrations, a known effect of beta-adrenergic stimulation, by addition of dibutyryl cAMP also enhanced LPS-induced IL-8 production. Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10. Hydrocortisone dose-dependently inhibited LPS-induced IL-8 production and reversed epinephrine-induced enhancement of IL-8 production. Epinephrine and hydrocortisone have opposite effects on IL-8 production, which may be relevant for the und...Continue Reading

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Citations

Jul 23, 1999·Annals of the New York Academy of Sciences·M P EversonW D Blackburn
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martijn D de KruifTom van der Poll
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Jan 5, 2008·Stroke; a Journal of Cerebral Circulation·Hakan AyA Gregory Sorensen
Jul 21, 2006·Annals of the New York Academy of Sciences·Jon D LevinePaul G Green
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Sep 14, 2017·Sleep Medicine·Xu WangFengxiu Ouyang

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