Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Arquivos de neuro-psiquiatria
Akbar AnaeigoudariMahmoud Hosseini

Abstract

Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI.

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Citations

Jan 30, 2019·Drug and Chemical Toxicology·Farimah BeheshtiAkbar Anaeigoudari
Jan 25, 2018·Arquivos de neuro-psiquiatria·Yousef BaghcheghiAkbar Anaeigoudari
Sep 4, 2016·Neurochemical Research·Anthony Taghogho EduviereOritoke Modupe Aluko
Jan 28, 2017·Metabolic Brain Disease·Farimah BeheshtiMahmoud Hosseini
Jan 25, 2017·Neurology Research International·Yousef BaghcheghiMahmoud Hosseini
Apr 14, 2017·Physiological Research·R ZakariaB Al-Rahbi
Nov 18, 2018·Metabolic Brain Disease·Zahra JahangiriMahmoud Hosseini
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Felipe Figueredo SaviCristiane Ritter

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