Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)

Molecular Medicine Reports
Junrong ZouDeqiang Huang

Abstract

Lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) exerts transcription factor activity and is involved in protein quality control. LITAF activity is highly dependent on correct translocation from the endosome/lysosome to the nucleus, while certain LITAF mutants mislocalize to areas, such as the cytosol and mitochondria, resulting in developmental diseases. In addition, previous studies have proposed that LITAF functions as a tumor suppressor and is frequently under‑represented in certain types of cancer. However, the mechanism of this phenomenon remains unclear. The present review summarizes the major advances in LITAF studies, and proposes that LITAF may serve as a switch in the balance between classical and alternative activation in tumor associated‑inflammation. Thus, LITAF may be a promising therapeutic target with regard to the tumor microenvironment.

References

Jun 27, 1996·The New England Journal of Medicine·F Bazzoni, B Beutler
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Sep 26, 1997·Nature·K PolyakB Vogelstein
Jun 3, 1999·The Journal of Cell Biology·J S Bonifacino, E C Dell'Angelica
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jun 15, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven H Itzkowitz, Xianyang Yio
Jun 16, 2004·International Journal of Cancer. Journal International Du Cancer·Yasuhiro MatsumuraYoshiki Miyachi
Mar 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiaoren TangSalomon Amar
Mar 10, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Léon C L van KempenLisa M Coussens
Apr 22, 2006·BMC Cancer·Mariana Fernandez-CoboBeatriz G T Pogo
Apr 22, 2006·Contributions to Microbiology·Karin E de Visser, Lisa M Coussens
Sep 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xiaoren TangSalomon Amar
Sep 13, 2006·Cancer Metastasis Reviews·Alberto MantovaniAntonio Sica
Apr 27, 2007·The Journal of Investigative Dermatology·Silvina GazzanigaRosa Wainstok
Nov 5, 2008·The Journal of Clinical Investigation·Fionula M Brennan, Iain B McInnes
Jan 6, 2009·Nature·Alberto Mantovani
Apr 9, 2010·Journal of Innate Immunity·Xiaoren TangSalomon Amar
Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·DeAnna A BakerGary S Gilkeson
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jamie C MerrillSalomon Amar
Jan 26, 2012·PloS One·Heather E EatonCraig R Brunetti
Oct 16, 2012·Journal of Cellular Physiology·Maria R GaldieroAlberto Mantovani
May 23, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marco LuigettiMauro Lo Monaco
Jun 2, 2014·Journal of the Neurological Sciences·Paola CiottiEmilia Bellone
Jun 4, 2014·The Journal of Clinical Investigation·Hengwei ZhangLianping Xing

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Citations

Aug 7, 2016·Journal of Medical Case Reports·Gaetano CarusoLeo Massari
Jan 13, 2018·BMC Systems Biology·Lichun Ma, Jie Zheng
Mar 17, 2019·International Journal of Molecular Sciences·Ruiqing YuQiong Xu
Apr 20, 2018·Pharmacological Reviews·Andrea ShergalisNouri Neamati
Feb 10, 2018·Oncotarget·Yuan ZhouCaide Lu
Jul 18, 2018·Molecular Medicine Reports·Xiaoyu Dong, Shuyan Cong
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyung Jin LimMun-Chual Rho
May 18, 2019·Cellular and Molecular Neurobiology·Changlin HuangGuanghui Li
Jan 8, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ha Na KimJin Boo Jeong
Oct 8, 2017·Functional & Integrative Genomics·C Cabreira-CagliariAlexandro Cagliari
Jul 1, 2020·Journal of Medicinal Food·Hyun Woo JeongWangi Kim
Feb 26, 2021·Journal of Cardiovascular Translational Research·Ye-Shi ChenKai Yin
Sep 10, 2020·Plant Science : an International Journal of Experimental Plant Biology·Fernanda ValandroAlexandro Cagliari
Apr 7, 2021·Journal of Molecular and Cellular Cardiology·Mei XiangManhua Chen
May 29, 2021·Poultry Science·Francesco PriscoOrlando Paciello

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