Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients

Shock
Martin PloderAndreas Spittler

Abstract

Multiple trauma patients have an impaired immune system and thus frequently develop life-threatening septic complications. Because there is an ongoing debate on which are the most predictive immunologic parameters of clinical outcome, we prospectively studied 19 multiple trauma patients with sepsis (mean age, 38.7 +/- 15.8 years; mean Injury Severity Score, 40.6 +/- 11.6) over a period of 14 days. The following parameters were measured daily after admission to the intensive care unit: ex vivo lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha) production, monocyte human leukocyte antigen (HLA)-DR expression, constitutive interleukin (IL) 6 secretion, white blood cell count, and C-reactive protein. In addition, procalcitonin, neopterin, LPS-binding protein, and constitutive TNF-alpha secretion were measured every third day. Immediately after trauma, all patients had significantly lower levels of HLA-DR and ex vivo LPS-stimulated TNF-alpha secretion than healthy controls (n = 7; P < 0.001). On the day after clinical diagnosis of sepsis, before any other parameter differed between survivors (n = 13) and nonsurvivors (n = 6), ex vivo LPS-induced TNF-alpha secretion was significantly lower (P < 0.05) in nonsurvi...Continue Reading

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Citations

Jan 8, 2011·Experimental Lung Research·Manuella LanzettiSamuel Santos Valenca
Mar 30, 2016·The Journal of Surgical Research·Bernhard KasperStefan Dhein
Jul 10, 2016·Journal of Complementary & Integrative Medicine·Sarah MousaviMohsen Meidani
Nov 30, 2019·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Ruiyi JiaAndrea B Maier
Jul 24, 2020·Scientific Reports·Norman J GalbraithSusan Galandiuk
Jun 1, 2011·Free Radical Research·Daniela ImpellizzeriSalvatore Cuzzocrea
Jul 13, 2019·Frontiers in Immunology·Tomasz SkireckiMarcin F Osuchowski
Dec 15, 2020·British Poultry Science·T TachibanaM A Cline
Feb 16, 2021·Frontiers in Physiology·Juliana Carvalho SantosAlessandra Gambero
Jun 1, 2008·Comprehensive Reviews in Food Science and Food Safety·M G SajilataR S Singhal

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