Lipopolysaccharide induces memory-processing deficits in day-old chicks

Pharmacology, Biochemistry, and Behavior
K M SellStephen Kent

Abstract

Recent evidence has demonstrated that immune activation can result in cognitive deficits due to the actions of the proinflammatory cytokines. These series of studies examined the effects of peripheral administration of lipopolysaccharide (LPS) on the memory processes of day-old chicks trained on a single-trial passive-avoidance task. LPS impaired performance in a dose- and time-dependent manner. Maximal impairment was produced by a dose of 2.5-mg/kg LPS administered 60 min prior to training. Retention tests revealed that deficits in memory processing appeared between 10 and 20 min posttraining. These results demonstrate an inhibitory effect of LPS on memory processing at the transition point from short-term memory to intermediate-term memory.

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Citations

Aug 28, 2004·Brain, Behavior, and Immunity·Lisa M Schrott, Sheldon B Sparber
Dec 24, 2002·The Journal of General Psychology·Susan J Larson
Jan 16, 2007·Behavioural Pharmacology·Stephen KentSimon F Crowe
Aug 8, 2014·Experimental Brain Research·Rana OmidbakhshLeila Dargahi
Jul 7, 2011·Respiratory Physiology & Neurobiology·A G HuxtableG S Mitchell
May 14, 2009·Brain, Behavior, and Immunity·Elisabeth G VichayaMary W Meagher
Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Allison C Hoffman, Sarah E Evans
Jul 22, 2008·Journal of Animal Science·T F BorderasJ Rushen
Oct 23, 2020·The International Journal of Neuroscience·Sachin P BorikarKishor R Danao
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Felipe Figueredo SaviCristiane Ritter

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