PMID: 7543075Jun 1, 1995Paper

Lipopolysaccharide priming of superoxide release by human neutrophils: role of membrane CD14 and serum LPS binding protein

Inflammation
L ShapiraT E Van Dyke

Abstract

Previous studies have suggested that lipopolysaccharide (LPS) interactions with neutrophils and monocytes are mediated via the CD14 receptor, in the presence of serum factors such as LPS-binding protein (LBP) and septin. The present study was designed to test if CD14-mediated LPS priming of human neutrophils is dependent upon the presence of serum proteins and to evaluate the contribution of serum factors in LPS-neutrophil interactions. The results demonstrate that CD14 mediates the priming of neutrophil superoxide release by LPS both in the presence and in the absence of serum. However, priming by LPS is greatly enhanced in the presence of human serum, and the factor responsible for this phenomenon is LBP and not heat-sensitive proteins, such as septin.

References

Mar 31, 1992·Biochemical and Biophysical Research Communications·K YasuiR I Sha'afi
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J L Rothstein, H Schreiber
Jan 1, 1994·The Journal of Experimental Medicine·E HailmanS D Wright

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Citations

Mar 1, 2012·Acta Pharmacologica Sinica·Lei Sun, Richard D Ye
Feb 7, 1998·The Journal of Clinical Investigation·F R DeLeoW M Nauseef
Sep 13, 2002·American Journal of Veterinary Research·Gabrielle LandoltKris T Kruse-Elliott
Nov 22, 2011·International Immunopharmacology·Maria Elisa Drago-SerranoRafael Campos-Rodríguez
Oct 3, 2002·Journal of Biochemistry and Molecular Biology·Laila N IslamNovera Sultana
Dec 25, 2008·The Journal of Nutrition·Daniel RusuPatrice E Poubelle
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Maureen MullarkeyDaniel P Rossignol
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·Douglas D BannermanPascal Rainard
Jun 4, 1999·Journal of Gastroenterology and Hepatology·K TsujiK Inoue

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