PMID: 8603989Feb 1, 1996Paper

Lipopolysaccharide regulates cysteine-rich intestinal protein, a zinc-finger protein, in immune cells and plasma

Journal of Leukocyte Biology
N A HallquistR J Cousins

Abstract

Cysteine-rich intestinal protein (CRIP), a double zinc-finger LIM protein, is expressed in great abundance in the intestine. We have found comparable levels of CRIP mRNA in peritoneal macrophages, peripheral blood mononuclear cells (PBMC), and lesser amounts in thymus and spleen. Because CRIP expression was high in immune cells, rats were challenged with lipopolysaccharide (LPS) to determine whether expression was altered during the acute-phase immune response. Immunocytochemistry showed that, in adherent mononuclear cells, CRIP protein was localized in the cytoplasm. CRIP mRNA levels increased over time after LPS injection in peritoneal macrophages, PBMC, spleen, and intestine. No changes in CRIP mRNA level were seen in either liver or thymus. In PBMC, the level of CRIP mRNA decreased before increasing later in the acute-phase immune response. CRIP protein was found in the plasma. Shortly after LPS administration plasma CRIP decreased, suggesting that CRIP was either passively diffused out of capillaries or was actively shunted into tissues to execute its function. Increased CRIP expression seen in response to LPS suggests that CRIP may play a role in immune cell activation or differentiation or in processes associated with ce...Continue Reading

Citations

May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Lorraine Lanningham-FosterRobert J Cousins
Dec 31, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maj HedtjärnHenrik Hagberg
Jul 4, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Marco van HamWiljan Hendriks
Mar 31, 2021·Clinical Science·Olga SchweigertTanja Zeller
Sep 30, 2021·The Kaohsiung Journal of Medical Sciences·Hong-Yu He, Li Hu
Feb 15, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Edward KellyDavid I Soybel

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