Lipopolysaccharide signaling induces serum amyloid A (SAA) synthesis in human hepatocytes in vitro

FEBS Letters
Kiyoshi MigitaHiromi Ishibashi

Abstract

To investigate the role of lipopolysaccharide (LPS) in hepatocyte activation, we examined the expression of Toll-like receptor 4 (TLR4), the putative receptor for LPS in human hepatocytes. TLR4 mRNA and protein expression was confirmed in human hepatocytes. Stimulation of human hepatocytes with LPS results in rapid degradation of IkappaB-alpha and mitogen activated protein kinase activation. Human hepatocytes stimulated by LPS produced serum amyloid A protein. Our data suggest that human hepatocytes utilize components of TLR4 signal transduction pathways in response to LPS and these direct LPS-mediated effects on hepatocytes may contribute to liver inflammation and injury.

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Citations

Aug 15, 2013·Veterinary Immunology and Immunopathology·Takashi TamamotoHajime Tsujimoto
Aug 16, 2011·Journal of Experimental Botany·Christine N PrinsElizabeth A H Pilon-Smits
Apr 24, 2008·Critical Care Medicine·Caroline AninatAndré Guillouzo
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Dec 15, 2020·Immunology·Sara Abouelasrar SalamaSofie Struyf
Nov 14, 2019·Cytokine & Growth Factor Reviews·Sara Abouelasrar SalamaSofie Struyf
Sep 18, 2021·Journal of Neuropathology and Experimental Neurology·Nora HuuskaMika Niemelä

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