Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA

FEBS Letters
Y HattoriS I Shimoda

Abstract

A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was observed in lung, heart and kidney of rats treated with lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in untreated rats, and remained elevated after LPS treatment. Parallel induction of nitric oxide synthase (NOS) mRNA was observed in these tissues of LPS-treated rats. Our results demonstrate induction of GTPCH mRNA after LPS treatment in vivo and provide molecular evidence for the increased GTPCH activity which may up-regulate NOS activity in vivo.

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Citations

Jul 25, 2009·Free Radical Biology & Medicine·Jeannette Vásquez-Vivar
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ian CookThomas S Leyh
Dec 3, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reiner WiestRoberto J Groszmann
Jan 28, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·Z S KatusicS Milstien
Nov 21, 2002·Critical Care Medicine·Hong-Yun LiZhi-Yong C Y Sheng
Dec 6, 1997·Biochemical and Biophysical Research Communications·Y HattoriK Kasai

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