PMID: 11918696Mar 29, 2002Paper

Lipopolysaccharide triggers invasive streptococcal disease in mice through a tumour necrosis factor-alpha-dependent mechanism

Immunology
Hongyan DiaoYimin

Abstract

Streptococcus pyogenes sometimes induces invasive streptococcal infection, including streptococcal toxic shock syndrome (STSS). Muscular necrosis is one of the peculiar symptoms of invasive streptococcal infection and STSS. We inoculated S. pyogenes into the muscles of mice. To do so, 5 x 10(8) bacteria in 0.2 ml phosphate-buffered saline were injected into the right hind thigh. None of the mice injected with the bacteria showed muscular necrosis and none died. Tumour necrosis factor-alpha (TNF-alpha) and infiltration of leucocytes were detected in the muscles of infected sites, although the condition of the infected mice did not deteriorate after anti-TNF-alpha monoclonal antibody treatment. The infected mice treated intraperitoneally with Escherichia coli lipopolysaccharide (LPS) showed augmentation of bacterial growth, muscular necrosis and death. TNF-alpha was detected in the sera of the infected mice treated with LPS, but not in the muscles of the infected sites. Infiltration of leucocytes into the infected muscle was not observed in the infected mice treated with LPS. Anti-TNF-alpha monoclonal antibody treatment decreased mortality in the infected mice treated with LPS. Moreover, the infected mice treated with recombinant...Continue Reading

References

Jan 1, 1995·Scandinavian Journal of Infectious Diseases·A Norrby-TeglundS E Holm
Jul 1, 1997·Infection and Immunity·M RoggianiP M Schlievert
Jul 1, 1997·Medicine·J C Bernaldo de QuirósE Bouza
Jul 23, 1999·Clinical Pediatrics·B A DuffJ A Lohr

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Citations

Dec 15, 2010·Microbial Pathogenesis·Mitsumasa SaitoShin-ichi Yoshida
Oct 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A FrostCharles H Lang
Nov 11, 2010·Scandinavian Journal of Infectious Diseases·Hongyan DiaoLanjuan Li

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