Lipoprotein (a) does not participate in the early acute phase response to training or extreme physical activity and is unlikely to enhance any associated immediate cardiovascular risk

Journal of Clinical Pathology
D J ByrneA F Winder

Abstract

To investigate the proposal that lipoprotein (a) (Lp(a)) contributes to the acute phase response and thus possibly to the acute cardiac risks associated with major physical effort. Fit, healthy, British army recruits were reviewed at the beginning and the end of a 10 week programme of basic training concluding with an intense 48 hour military exercise. Final recruit assessment was staggered over the last week of training, giving rise to six recruit groups, with determination of Lp(a), C reactive protein (CRP), fibrinogen, albumin, and total creatine kinase values from 12 hours to five days after the final exercise. A clear acute phase response was seen following the final exercise, marked by a significant increase in circulating concentrations of fibrinogen and a reduction of albumin, and a trend with non-significant increases in CRP. Lp(a) did not behave as an early marker of the acute response. Previous reports may have been confounded by concurrent disease in older subjects and by late sampling. Lp(a) determination for cardiovascular risk profiling is not confounded by associated physical effort. It is also unlikely that the acute risks of major physical effort are enhanced by any process involving Lp(a).

References

Sep 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·W Y Craig, T B Ledue
Apr 1, 1992·American Journal of Obstetrics and Gynecology·R A LoboW L Paul
Nov 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S OshimaK Haze
Feb 1, 1986·Metabolism: Clinical and Experimental·B DufauxW Hollmann
Dec 13, 1995·JAMA : the Journal of the American Medical Association·V M MaherJ J Albers
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·T B LedueW Y Craig
Jan 1, 1994·Chemistry and Physics of Lipids·A NomaK Shimokawa
Jul 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·S Wållberg-JonssonS Rantapää-Dahlqvist
Sep 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·D T VallanceA F Winder
Sep 1, 1993·British Journal of Sports Medicine·E Ernst
Apr 26, 1996·Atherosclerosis·I HolmeI Hjermann
Jun 6, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·G LippiG Guidi
Jan 23, 1999·The American Journal of Cardiology·S M Marcovina, M L Koschinsky
Aug 29, 2000·Journal of Clinical Pathology·H J MilionisD P Mikhailidis
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults

❮ Previous
Next ❯

Citations

Jul 29, 2010·Cerebrovascular Diseases·Bernadette Boden-AlbalaLars Berglund
Mar 8, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiGian Cesare Guidi
Apr 20, 2006·Journal of Thrombosis and Thrombolysis·Antonio Tello-MontoliuFrancisco Marín
Dec 14, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Emmanuel S GanotakisDimitri P Mikhailidis
Jul 29, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A BrandstätterF Kronenberg
Feb 19, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Hai-hua YangMin-hua Ye
May 7, 2009·Current Opinion in Cardiology·Konstantinos TziomalosDimitri P Mikhailidis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Risk Prediction

Cardiovascular risk prediction models based on classical risk factors identified in epidemiological studies are useful in primary prevention of cardiovascular disease in individuals. Here is the latest research.

Related Papers

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Handan MisirliNuri Yaşar Erenoğlu
Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
George U Liepa, Hemendra Basu
© 2022 Meta ULC. All rights reserved