Lipoprotein (a) levels and outcomes in stable outpatients with symptomatic artery disease

Atherosclerosis
Juan Francisco Sánchez Muñoz-TorreroFRENA Investigators

Abstract

Although genetic and epidemiological studies support that people with high lipoprotein (a) [Lp(a)] levels are at an increased risk for arterial disease, its prognostic value in patients with established artery disease has not been consistently evaluated. FRENA is a prospective registry of consecutive outpatients with coronary, cerebrovascular or peripheral artery disease. We assessed the risk for subsequent myocardial infarction, ischemic stroke or limb amputation according to Lp(a) levels at baseline. As of December 2016, 1503 stable outpatients were recruited. Of these, 814 (54%) had levels <30 mg/dL, 319 (21%) had 30-50 mg/dL and 370 (25%) had ≥50 mg/dL. Over a mean follow-up of 36 months, 294 patients developed subsequent events (myocardial infarction 122, ischemic stroke 114, limb amputation 58) and 85 died. On multivariable analysis, patients with Lp(a) levels of 30-50 mg/dL were at a higher risk for myocardial infarction (hazard ratio [HR]: 4.67; 95%CI: 2.77-7.85), ischemic stroke (HR: 8.27; 95%CI: 4.14-16.5) or limb amputation (HR: 3.18; 95%CI: 1.36-7.44) than those with normal levels. Moreover, patients with levels ≥50 mg/dL were at increased risk for myocardial infarction (HR: 19.5; 95%CI: 10.5-36.1), ischemic stroke ...Continue Reading

Citations

Mar 16, 2019·Clinical Research in Cardiology Supplements·Norbert Weiss, Ulrich Julius
Oct 3, 2019·Current Opinion in Lipidology·Jonathan GolledgeGerald F Watts
Mar 9, 2019·Current Atherosclerosis Reports·Željko Reiner
Aug 31, 2020·Journal of Atherosclerosis and Thrombosis·Koji YanakaMasaharu Ishihara
Jan 1, 2021·Archives of Medical Research·Georgia AnastasiouEvangelos Liberopoulos
Apr 28, 2020·The American Journal of Cardiology·Nishant P ShahManesh R Patel
Mar 6, 2021·European Journal of Clinical Investigation·Javier Galán-GonzálezUNKNOWN for FRENA Investigators
Apr 29, 2019·Journal De Médecine Vasculaire·J P Laroche
Jun 11, 2021·Circulation Research·Marc P BonacaMark A Creager
Aug 15, 2021·European Journal of Preventive Cardiology·Ioannis ParthymosMatilda Florentin
Dec 16, 2021·European Journal of Clinical Investigation·Carmen Sánchez-BacaicoaUNKNOWN for FRENA Investigators

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