PMID: 8593125Oct 1, 1995Paper

Lipoprotein (a)

Baillière's Clinical Endocrinology and Metabolism
P N Durrington

Abstract

Lipoprotein (a) is similar to low-density lipoprotein but is unique in having an additional apolipoprotein called apolipoprotein (a) (apo(a)) covalently linked to it. apo(a), which is a member of the plasminogen gene superfamily, has a protease domain which cannot be activated to cause fibrinolysis. Its sequence of kringles is much longer than that of plasminogen and there is remarkable genetic variation in its length. The consequent inherited differences in apo(a) molecular mass are largely responsible for the wide range of serum Lp(a) concentrations in different individuals with low levels predominating in Europid populations. Physiologically Lp(a) may participate in haemocoagulation or in wound-healing. Epidemiological evidence that it is a risk factor for atherosclerosis, particularly in populations with high serum LDL levels, has led to research to uncover its role in atherogenesis and thrombosis. Diseases such as renal disease, and probably atherogenesis and thrombosis. Diseases such as renal disease, and probably atherosclerosis itself, are associated with an increase in Lp(a) above its genetically determined level and it remains a subject of speculation as to whether such increases are as closely involved in atherothrom...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Investigation·E BoerwinkleH H Hobbs
Oct 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C SandholzerG Utermann
Nov 1, 1992·Metabolism: Clinical and Experimental·M NaruszewiczJ Davignon
Nov 1, 1992·Metabolism: Clinical and Experimental·M NaruszewiczJ Davignon
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N MalgarettiD LePaslier
Feb 29, 1992·BMJ : British Medical Journal·J FeelyT Cooke
Jan 1, 1992·Atherosclerosis·D CrookJ C Stevenson
Jul 1, 1992·Annals of Internal Medicine·L C RamirezP Raskin
May 15, 1992·The American Journal of Cardiology·G SigurdssonN Sigfusson
Oct 1, 1991·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·W MärzW Gross
Jan 4, 1991·Biochimica Et Biophysica Acta·W SattlerH Esterbauer
Mar 1, 1991·The Journal of Clinical Investigation·T F ZioncheckR M Lawn
Feb 1, 1991·Stroke; a Journal of Cerebral Circulation·J WooM G Nicholls
May 25, 1991·The American Journal of Cardiology·J GenestE J Schaefer
Jun 15, 1991·The American Journal of Cardiology·E von HodenbergC Bode
Jun 1, 1991·Annals of the Rheumatic Diseases·S Rantapää-DahlqvistG Dahlén
Apr 1, 1991·Diabetes Care·S M HaffnerD L Rainwater
Jul 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A D MbewuJ P Miller
Jun 1, 1991·European Journal of Vascular Surgery·O NorrgårdG Dahlen
Sep 21, 1991·BMJ : British Medical Journal·H KapelrudK F Hanssen
Sep 21, 1991·BMJ : British Medical Journal·E FarishD M Hart
Nov 1, 1991·Metabolism: Clinical and Experimental·M VälimäkiM R Taskinen
Oct 1, 1991·Atherosclerosis·P de KnijffL M Havekes
Dec 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·P H WinocourP N Durrington
Jun 1, 1990·The Journal of Clinical Investigation·A M Scanu, G M Fless

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Citations

Jan 1, 1997·International Journal of Clinical & Laboratory Research·M L Koschinsky, S M Marcovina
May 28, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·S C RiemensR P Dullaart
Oct 18, 2003·Clinical Biochemistry·Azza H AbouGhaliaMohamed F El-Badrawy
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·E R ChristD L Russell-Jones
Dec 15, 2000·European Journal of Clinical Investigation·P M SweetnamJ W Yarnell
May 23, 2001·Protein Science : a Publication of the Protein Society·Q YeZ Jia
Dec 3, 2014·Gene·Ana Emília Holanda RolimLuzimar Gonzaga Fernandez
Sep 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·M L RandM L Koschinsky
Mar 31, 1998·Clinical Genetics·M L KoschinskyB R Gabel
Nov 13, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·B R GabelM L Koschinsky
Jul 1, 2014·Current Opinion in Lipidology·Paul N DurringtonHandrean Soran
Jun 17, 2004·Circulation·Rafael CarmenaJean-Charles Fruchart
Apr 13, 2000·Mayo Clinic Proceedings·I J KulloA J Tajik

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