Lipoprotein apheresis downregulates IL-1α, IL-6 and TNF-α mRNA expression in severe dyslipidaemia

Atherosclerosis. Supplements
Claudia StefanuttiMoritz Fischer

Abstract

Dyslipidaemias are associated with cardiovascular mortality and morbidity, driven by unstable atherosclerotic plaques with inflammatory infiltrates. Levels of messenger RNA (mRNA) for pro-inflammatory cytokines have been positively correlated with atherosclerotic disease progression. Therapeutic lipoprotein apheresis (LA) reduces plasma lipid levels and reduces inflammation. We evaluated the effects of LA on expression of mRNA coding for key pro-inflammatory cytokines in patients with dyslipidaemia, homo-/hetero-zygous familial hypercholesterolaemia (HoFH, HeFH) or hyperlipoprotein(a)aemia [hyperLp(a)] and associated coronary artery disease (CAD). Ten patients (five males and five females, mean age 47 ± 9.2 years) were enrolled, all with HyperLp(a) or confirmed genetic diagnoses of dyslipidaemia, HoFH, or HeFH; all had associated CAD. mRNA determinations were via reverse transcriptase polymer chain reaction (RT-qPCR). LA was associated with downregulation of mRNA expression for IL-1α, IL-6 and TNF-α, starting after the first LA session. The observed reduction was progressively enhanced during the interval between the first and second LA sessions to achieve a maximum decrease by the end of the second session (IL-1α: -49%, p < 0....Continue Reading

Citations

Nov 30, 2019·Journal of Clinical Apheresis·Randolf HardersenAnders Hovland
Feb 23, 2020·Journal of Clinical Apheresis·Lucia MerolleThelma A Pertinhez
Jul 11, 2019·European Journal of Preventive Cardiology·Fabrizio MontecuccoAmirhossein Sahebkar
Dec 7, 2018·European Journal of Preventive Cardiology·Ivana VeljićPetar M Seferović
Jul 28, 2020·Current Atherosclerosis Reports·Patrick M MoriartySotirios Tsimikas

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