PMID: 16503872Mar 1, 2006Paper

Lipoprotein-associated phospholipase A2: a potential therapeutic target for atherosclerosis

Current Drug Targets. Cardiovascular & Haematological Disorders
A ZalewskiJ J Nelson

Abstract

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells, is bound to circulating LDL, and is involved in hydrolyzing polar phospholipids, including those found in oxidized low-density lipoproteins. To date, the biological role of Lp-PLA(2) in atherogenesis has been controversial, with initial reports purporting an atheroprotective effect attributable to the degradation of platelet activating factor and similar molecules. However, more recent studies suggest a proatherogenic role for this enzyme, which is attributed to Lp-PLA(2)-mediated hydrolysis of oxidatively modified low-density lipoproteins that results in the accumulation of proinflammatory products. The liberation of lysophosphatidylcholine and oxidized nonesterified fatty acids from oxidized phospholipids by the action of Lp-PLA(2) results in diverse inflammatory effects on various cell types involved in atherogenesis. This concept is further supported by a number of recently published epidemiology studies suggesting that plasma levels of the enzyme predict future cardiovascular events independent of conventional risk factors. The development of selective inhibitors of Lp-PLA(2) that inhibit enzyme activity in the circul...Continue Reading

Citations

Jan 4, 2012·Nature Reviews. Drug Discovery·Daniel A Bachovchin, Benjamin F Cravatt
Jun 6, 2012·Journal of Lipid Research·Robert S Rosenson, Diana M Stafforini
Mar 9, 2012·The Journal of Clinical Endocrinology and Metabolism·T L NelsonK J Mukamal
May 4, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ariadne AvellinoGregory J Fermann
Dec 17, 2009·Progress in Cardiovascular Nursing·Joung Hee Lee, Marguerite M Engler
Aug 21, 2007·Molecular Diagnosis & Therapy·Natalie Khuseyinova, Wolfgang Koenig
Mar 25, 2019·Diabetes Research and Clinical Practice·Yun HuJian-Hua Ma
Jun 13, 2021·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisBasant K Puri

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