Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review

Journal of Clinical Lipidology
Adnan YounusKhurram Nasir

Abstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that exhibits proinflammatory properties and has been associated with subclinical cardiovascular disease. The relationship between Lp-PLA2 and subclinical CVD remains unclear. The goal of this systematic review was to clarify this relationship. An extensive literature search of the MEDLINE database using Ovid and PubMed was performed. From an initial search of 444 articles, 13 met the inclusion and exclusion criteria and were included in the review. Of the 13 studies included in the review, 6 examined the relationship between Lp-PLA2 and coronary artery calcification, of which 3 showed a significant correlation. Two studies examined the relationship between Lp-PLA2 and endothelial dysfunction, and 1 reported a significant relationship. Five studies investigated the association of Lp-PLA2 with carotid intima-media thickness (CIMT), and 3 reported a significant relationship. This review shows a variable association between Lp-PLA2 and subclinical disease. This finding has broad implications for the future of public health and clinical practice. Future research is needed to clarify what role Lp-PLA2 has in guiding treatment and if it is involved in plaque instability, ...Continue Reading

Citations

Feb 10, 2018·Journal of Cellular and Molecular Medicine·Youxin WangYong Zhou
Jul 26, 2018·Journal of Clinical Laboratory Analysis·Danchen WangLing Qiu
Jan 20, 2020·International Urology and Nephrology·Joanna JagiełaJacek Rysz
Jun 1, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Min WangRui Song
Jul 3, 2021·Journal of Clinical Medicine·Ana María Pello LázaroJosé Tuñón
Mar 20, 2020·Current Vascular Pharmacology·Dimitrios PatouliasCharles Faselis

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