Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population

Atherosclerosis
Hirotsugu UeshimaACCESS and SESSA Research Groups

Abstract

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme predominantly bound to low-density lipoprotein (LDL). Lp-PLA2 is recognized as playing a key role in inflammatory processes and the development of atherosclerosis. This study aimed to investigate whether Lp-PLA2 is related to subclinical atherosclerosis, independently from traditional risk factors, in a general Japanese population by analyses of both the observational study and Mendelian randomization using V279F polymorphism. We cross-sectionally examined community-based sample of 929 Japanese men aged 40-79 years, without statin treatment, who were randomly selected from the resident registration. Multiple regression analyses of Lp-PLA2 activity and concentration were undertaken separately for men aged 40-49 years and 50-79 years, to clarify interactions of age and Lp-PLA2. Lp-PLA2 activity for men aged 50-79 years was significantly and positively related to intima-media thickness (IMT) (P = 0.013) and plaque index (P = 0.008) independent of traditional risk factors including small LDL particles, but not to coronary artery calcification (CAC) score. Associations with Lp-PLA2 concentration were qualitatively similar to those of activity. Corresponding relationships...Continue Reading

References

Feb 11, 1992·Stroke; a Journal of Cerebral Circulation·K Sutton-TyrrellS F Kelsey
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Nov 7, 2002·The American Journal of Cardiology·James D OtvosWilliam C Cromwell
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Feb 13, 2007·Mayo Clinic Proceedings·Carolina A GarzaFrancisco Lopez-Jimenez
Aug 2, 2008·Journal of the American College of Cardiology·Akira SekikawaUNKNOWN ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort
Aug 12, 2009·Current Opinion in Lipidology·Robert L Wilensky, Colin H Macphee
Nov 26, 2009·Nature Reviews. Nephrology·Florian Kronenberg
May 4, 2010·Lancet·Robert S Rosenson
Jul 17, 2012·JAMA : the Journal of the American Medical Association·Emanuele Di AngelantonioJohn Danesh
Apr 1, 2014·The New England Journal of Medicine·Harvey D WhiteLars Wallentin
Sep 1, 2014·JAMA : the Journal of the American Medical Association·Michelle L O'DonoghueDylan L Steen

❮ Previous
Next ❯

Citations

Oct 11, 2016·Expert Opinion on Therapeutic Patents·Maroula G KokotouGeorge Kokotos
Feb 10, 2018·Journal of Cellular and Molecular Medicine·Youxin WangYong Zhou
Dec 8, 2017·Journal of Atherosclerosis and Thrombosis·UNKNOWN Tai PhamUNKNOWN Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group
Jul 27, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Itsuko MiyazawaUNKNOWN SESSA Research Group
Jun 26, 2018·Journal of Hypertension·Takashi HisamatsuUNKNOWN SESSA Research Group
Feb 21, 2018·Journal of Atherosclerosis and Thrombosis·Ruriko Seto-YukimuraUNKNOWN SESSA Research Group
Feb 14, 2019·Circulation. Cardiovascular Imaging·Takashi HisamatsuHirotsugu Ueshima
May 17, 2019·Journal of Atherosclerosis and Thrombosis·Yuyan LiuUNKNOWN SESSA Research Group
May 30, 2019·Medicinal Research Reviews·Fubao HuangJianhua Shen
Jul 28, 2017·Journal of Atherosclerosis and Thrombosis·Sentaro SuzukiUNKNOWN SESSA Research Group
Jan 24, 2020·Journal of Atherosclerosis and Thrombosis·Md Maruf Haque KhanUNKNOWN SESSA Research Group
Feb 23, 2017·The Journal of International Medical Research·Li YangHongliang Cong
Jul 28, 2018·European Journal of Clinical Nutrition·Akira SekikawaUNKNOWN SESSA Research Group
Aug 31, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sayaka KadowakiUNKNOWN SESSA Research Group
Nov 6, 2020·Stroke; a Journal of Cerebral Circulation·Mohammad MoniruzzamanUNKNOWN SESSA Research Group
Jan 12, 2021·Journal of Physical Activity & Health·Mohammad MoniruzzamanUNKNOWN SESSA Research Group
Feb 9, 2021·Journal of Atherosclerosis and Thrombosis·Maryam ZaidUNKNOWN SESSA Research Group
Dec 6, 2020·Alcohol·Ali Haidar SyaifullahUNKNOWN Research members
Apr 6, 2021·Journal of Alzheimer's Disease : JAD·Naoko MiyagawaKamal Masaki
Jun 8, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Thien VuUNKNOWN Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.