Lipoprotein-associated phospholipase A(2) mass and activity and risk of cardiovascular disease in a population with high prevalences of obesity and diabetes: the Strong Heart Study.

Diabetes Care
J R KizerBarbara V Howard

Abstract

To investigate the association of lipoprotein-associated phospholipase A(2) (LpPLA(2)) mass and activity with incident cardiovascular disease (CVD) in a population with high prevalences of insulin resistance and diabetes, conditions for which epidemiological data remain sparse. We conducted a nested, case-control study (n = 1,008) within a population-based cohort of American Indians. Case subjects were defined by incidence of first-ever CVD up to 10 years later. Control subjects comprised participants free of CVD events during the follow-up period who were frequency matched to case subjects by age, sex, and diabetes status. LpPLA(2) mass and activity were measured using commercially available assays. LpPLA(2) mass and activity were moderately correlated with each other (r = 0.30), but only LpPLA(2) activity exhibited moderate correlations with lipid fractions. After extensive adjustment for covariates, both LpPLA(2) measures were significantly associated with incident CVD, but the relationship was inverse for LpPLA(2) mass (highest versus lowest tertile, relative risk [RR] 0.55 [95% CI 0.39-0.79]) and positive for LpPLA(2) activity (highest versus lowest tertile, 1.65 [1.12-2.42]). These associations were similar when participa...Continue Reading

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D M StafforiniS M Prescott
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Mar 31, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·W Q LuB V Howard
May 27, 2004·Diabetes Care·Ronald M Krauss
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert S LindsayLyle G Best
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew Zalewski, Colin Macphee
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Jul 14, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Sotirios TsimikasAlexandros D Tselepis
Mar 11, 2009·Biochimica Et Biophysica Acta·Constantinos C Tellis, Alexandros D Tselepis
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·G K Hansson
Nov 6, 2010·Journal of Internal Medicine·UNKNOWN Heart Protection Study Collaborative Group

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Citations

Aug 7, 2013·Cardiovascular Diabetology·Jose Luis Sánchez-QuesadaAntonio Pérez

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

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