Lipoprotein cholesterol and atherosclerosis

Current Molecular Medicine
H S Kruth

Abstract

Progressive accumulation of cholesterol in the arterial wall causes atherosclerosis, the pathologic process underlying most heart attacks and strokes. Low density lipoprotein (LDL), the major carrier of blood cholesterol, has been implicated in the buildup of cholesterol in atherosclerotic plaques. Endothelial cells that line arteries function to transport LDL into the vessel wall. Models for the mechanism of cholesterol accumulation in atherosclerotic plaques emphasize increased LDL uptake into the vessel wall or increased retention of LDL that has entered the vessel wall. This article reviews the pathways of cholesterol entry and removal, the metabolism, and the physical changes of cholesterol in the vessel wall. How these processes are believed to contribute to cholesterol buildup in atherosclerotic plaques is discussed.

Citations

Apr 29, 2010·Current Atherosclerosis Reports·Kiyoko Uno, Stephen J Nicholls
Apr 13, 2005·Atherosclerosis. Supplements·Philip Barter
Dec 4, 2003·Biochemical and Biophysical Research Communications·Elizabeth H MooreKathleen M Botham
Nov 6, 2009·Antioxidants & Redox Signaling·Irena LevitanPapasani V Subbaiah
Jul 17, 2012·Journal of Clinical Biochemistry and Nutrition·Paula R AugustiTatiana Emanuelli
Sep 27, 2008·Journal of Clinical Biochemistry and Nutrition·Zulkhairi AmomMohd Kamal Nik Hassan
Jul 7, 2009·European Journal of Pharmacology·Hitesh VaidyaRamesh Goyal
Jun 10, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A ZulkhairiA Zanariyah
Jun 24, 2009·IUBMB Life·Irena Levitan
Sep 11, 2004·Biochemical and Biophysical Research Communications·Bin ZhaoHoward S Kruth
Aug 26, 2006·Biochemical and Biophysical Research Communications·Hong-Tao MaHoward S Kruth
Jan 20, 2011·Biophysical Journal·Avia Rosenhouse-DantskerIrena Levitan
Jul 22, 2015·Biochimica Et Biophysica Acta·Anna N BukiyaAvia Rosenhouse-Dantsker
Dec 3, 2013·Molecular and Cellular Endocrinology·Gaia FaveroRita Rezzani
Apr 30, 2016·Journal of Ethnopharmacology·Lorena Neris BarbozaArquimedes Gasparotto
Dec 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Caroline CoisneFabien Gosselet
May 19, 2017·The American Journal of Chinese Medicine·Sun Haeng ParkHo Kyoung Kim
Apr 10, 2008·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Yehuda KamariDror Harats
Jan 16, 2013·Journal of Dental Research·M MorishitaT Nishihara
Jan 25, 2007·Physiological Genomics·Hyung Jun ChoKlaus Ley
Sep 20, 2019·Biomolecules·Maurizio Balestrino, Enrico Adriano
Oct 1, 2019·Archives of Physiology and Biochemistry·Samah Fathy AhmedWalid Hamdy El-Tantawy
May 7, 2016·British Journal of Clinical Pharmacology·Simone MarconeDesmond J Fitzgerald
Apr 1, 2009·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Jean Ferrières
Nov 9, 2011·Expert Review of Cardiovascular Therapy·Stephen J NichollsYu Kataoka
Feb 19, 2017·The Journal of Biological Chemistry·Anna N BukiyaAvia Rosenhouse-Dantsker
May 7, 2019·Frontiers in Cellular and Infection Microbiology·Shyamala Thirunavukkarasu, Shabaana A Khader
May 16, 2020·Mediators of Inflammation·Donisha Shani Niharika Keembiya Liyanagamage, Ryan D Martinus

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