Abstract
The young-onset diabetes seen in HNF1A-MODY is often misdiagnosed as Type 2 diabetes. Type 2 diabetes, unlike HNF1A-MODY, is associated with insulin resistance and a characteristic dyslipidaemia. We aimed to compare the lipid profiles in HNF1A-MODY, Type 2 diabetes and control subjects and to determine if lipids can be used to aid the differential diagnosis of diabetes sub-type. 1) 14 subjects in each group (HNF1A-MODY, Type 2 diabetes and controls) were matched for gender and BMI. Fasting lipid profiles and HDL lipid constituents were compared in the 3 groups. 2) HDL-cholesterol was assessed in a further 267 patients with HNF1A-MODY and 297 patients with a diagnosis of Type 2 diabetes to determine its discriminative value. 1) In HNF1A-MODY subjects, plasma-triglycerides were lower (1.36 vs. 1.93 mmol/l, p = 0.07) and plasma-HDL-cholesterol was higher than in subjects with Type 2 diabetes (1.47 vs. 1.15 mmol/l, p = 0.0008), but was similar to controls. Furthermore, in the isolated HDL; HDL-phospholipid and HDL-cholesterol ester content were higher in HNF1A-MODY, than in Type 2 diabetes (1.59 vs. 1.33 mmol/L, p = 0.04 and 1.10 vs. 0.83 mmol/L, p = 0.019, respectively), but were similar to controls (1.59 vs. 1.45 mmol/L, p = 0.35...Continue Reading
References
Jan 1, 1975·Diabetes·R B Tattersall, S S Fajans
Feb 23, 1996·Cell·M PontoglioM Yaniv
Mar 21, 1997·Atherosclerosis·J McEnenyI S Young
Apr 30, 1998·Diabetologia·B IsomaaL Groop
May 5, 1998·Molecular and Cellular Biology·Y H LeeF J Gonzalez
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·S P LaingH Keen
Sep 6, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·E R PearsonA T Hattersley
Jan 11, 2001·Diabetologia·D TripathyL Groop
Mar 30, 2001·Nature Genetics·D Q ShihM Stoffel
May 26, 2001·The American Journal of Cardiology·D J Maron
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·K R OwenA T Hattersley
Oct 28, 2003·Diabetes Care·Maggie ShepherdAndrew T Hattersley
Nov 25, 2003·Diabetes·Symi RichterMarkus Stoffel
Nov 26, 2003·European Journal of Clinical Investigation·S E BorggreveR P F Dullaart
Apr 28, 2004·Diabetes Care·Ewan R PearsonAndrew T Hattersley
Jun 29, 2005·Diabetes Care·Amanda StrideAndrew T Hattersley
Aug 4, 2006·The New England Journal of Medicine·Ewan R PearsonUNKNOWN Neonatal Diabetes International Collaborative Group
Jun 21, 2007·Diabetologia·A HoangD Sviridov
Mar 14, 2008·The Review of Diabetic Studies : RDS·Jan SkupienMaciej T Malecki
Jun 3, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·E KarlssonL Groop
Apr 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·M ShepherdA T Hattersley
Jan 30, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Estelle NobécourtKerry-Anne Rye
May 26, 2010·Diabetologia·B M ShieldsS Ellard
Jun 16, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A M SteeleE R Pearson
Jul 17, 2010·Current Diabetes Reports·Dana DabeleaGiuseppina Imperatore
Aug 21, 2010·Diabetes Care·Katharine R OwenAnna L Gloyn
Sep 14, 2010·International Journal of Clinical Practice·M RizzoA S Manolis
Jun 28, 2011·Diabetes Care·Tim J McDonaldAndrew T Hattersley
Citations
Feb 20, 2014·Acta Diabetologica·Wojciech FendlerWojciech Mlynarski
Feb 22, 2016·Canadian Journal of Diabetes·Carl-Hugo Lachance
Jan 26, 2013·Human Mutation·Kevin ColcloughSian Ellard
Nov 20, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·S A MughalK R Owen
May 21, 2014·Journal of Diabetes Investigation·Valerie M Schwitzgebel
Dec 17, 2014·European Journal of Endocrinology·Magdalena SzopaMaciej T Malecki
May 5, 2016·BMC Medical Genetics·Birgit KnebelDirk Muller-Wieland
Oct 20, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·S BaconM M Byrne
May 1, 2016·Canadian Journal of Diabetes·Shazhan Amed, Richard Oram
Aug 12, 2016·Obstetric Medicine·Rinki Murphy
Jun 8, 2017·The Journal of Gene Medicine·Xiaojing WangMin Nie
Jan 1, 2013·Genes·Richard W Carroll, Rinki Murphy
May 15, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jeffrey W KleinbergerToni I Pollin
Sep 14, 2019·Endocrine Regulations·Terezia ValkovicovaDaniela Gasperikova
Jul 30, 2017·Archives of Disease in Childhood. Education and Practice Edition·Emma M Dyer, Rakesh Amin
Aug 30, 2018·Journal of Diabetes Research·Xiuting HuangLinong Ji
Jun 6, 2018·Frontiers in Endocrinology·Parveena FirdousShariq Rashid Masoodi
Mar 19, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mengdie HuLinong Ji
Jul 18, 2018·Frontiers in Endocrinology·Jana UrbanováJan Brož
Dec 31, 2019·Current Diabetes Reviews·Madalena Sousa, Jácome Bruges-Armas
Apr 14, 2021·Endocrinología, Diabetes Y Nutrición·Efrain Cordero-VázquezAndreea Ciudin
Aug 28, 2021·International Journal of Molecular Sciences·Barbara PucelikAnna Czarna
Jan 25, 2020·Clinical Diabetes : a Publication of the American Diabetes Association·Karen L ShidlerLucia M Novak
Dec 25, 2021·Diabetologia·Jarno L T KettunenTiinamaija Tuomi