Lipoprotein-induced prostacyclin production in endothelial cells and effects of lipoprotein modification.

The American Journal of Physiology
D E MyersR G Larkins

Abstract

Although lipoprotein modification has been implicated in atherogenesis, the effect of modified forms of lipoproteins on vascular cell function has not been fully resolved. We have investigated lipoprotein-induced prostaglandin production by macrovascular endothelial cells. This study delineates early responses of endothelial cells after exposure to native and modified forms of the lipoproteins. Modification of lipoproteins by oxidation or glycation significantly affected the capacity of lipoproteins to induce prostacyclin (PGI2) production by bovine aortic endothelial cells (BAEC). Modified low-density lipoprotein (LDL) increased PGI2 production in the short term (up to 24 h), but oxidized LDL caused an inhibition of PGI2-producing capacity in longer term incubations (48-72 h). Glycated (Glc) high-density lipoprotein 3 (HDL3) caused higher production of PGI2 in the short term (4-24 h) but reached similar levels as HDL3 over time. Glycation of high-density lipoprotein 2 had no effect on the PGI2-producing capacity of the lipoprotein. Thus modification of the lipoproteins affects their potential to induce PGI2 production in endothelial cells, and this may have an influence on vascular function in disease states such as diabetes a...Continue Reading

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Citations

Jun 10, 2006·Circulation Research·Chieko MineoPhilip W Shaul
Dec 6, 2005·Journal of Biomedical Science·Giovanni Maria PudduPaolo Puddu
Jun 4, 2008·Current Opinion in Cardiology·Matilda FlorentinDimitri P Mikhailidis
Jun 6, 2009·Antioxidants & Redox Signaling·Anne Negre-SalvayreManuel Portero-Otín
Nov 24, 2016·Clinical Chemistry·Sotirios K KarathanasisAlan T Remaley
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Oct 23, 1997·Thrombosis Research·C PirichH Sinzinger
Mar 8, 2002·Atherosclerosis·Jerzy-Roch NoferArnold von Eckardstein

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