Lipoprotein lipase during continuous heparin infusion: tissue stores become partially depleted

The Journal of Laboratory and Clinical Medicine
Birgit NasstromBernd G Stegmayr


Lipoprotein lipase (LPL) and hepatic lipase (HL) are located at vascular surfaces in extrahepatic tissues and in the liver, respectively. Heparin displaces the enzymes into the circulating blood. Animal studies have shown that the liver takes up and degrades LPL. To explore whether heparin leads to a depletion of tissue stores, we followed the lipase activities in plasma during an 8-hour primed infusion of heparin in 10 healthy subjects. After an initial peak, the HL activity decreased slowly after a time curve similar to that for activated partial thromboplastin time. The time curve for LPL was different. After the initial peak, the activity dropped by almost 80%, from 30 to 120 minutes, and then leveled off to a plateau that corresponded to about 15% of the peak level. A second bolus of heparin was given to 4 subjects after 4 hours. The plasma LPL activity increased, but only to about 35% of the original peak level. We conclude that when heparin releases LPL into plasma, the lipase becomes liable to be taken up and degraded by the liver. After less than 1 hour, the stores of LPL have been exhausted, and recruitment of lipase into plasma depends on a slow but stable delivery of newly synthesized molecules.


Jan 1, 1991·Advances in Experimental Medicine and Biology·Thomas OlivecronaJ Patsch
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·U SaxenaI J Goldberg
Nov 12, 1990·Biochimica Et Biophysica Acta·D M Goldberg, T Chajek-Shaul
Apr 1, 1987·Acta Anaesthesiologica Scandinavica·E PerssonE Vinnars
Jul 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·P J Nestel
Oct 4, 1984·Biochimica Et Biophysica Acta·L WallinderG Bengtsson-Olivecrona
Nov 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·M ArnadottirP Nilsson-Ehle
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·O ChevreuilThomas Olivecrona
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·O ChevreuilThomas Olivecrona
Dec 1, 1996·The Biochemical Journal·O ChevreuilThomas Olivecrona
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·P W Connelly


Jun 7, 2007·Internal and Emergency Medicine·G B VignaM Trovati
Apr 25, 2012·Clinical Research in Cardiology Supplements·Nils Ewald, Hans-Ulrich Kloer
Mar 31, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Birgit NasstromThomas Olivecrona
Nov 17, 2004·BMC Physiology·Lucyna NeugerGunilla Olivecrona
Mar 29, 2003·American Journal of Veterinary Research·Margarethe HoenigDuncan C Ferguson
Jul 28, 2012·Indian Journal of Endocrinology and Metabolism·Aalok D Patel
Feb 23, 2017·Archives of Endocrinology and Metabolism·Mohammad Shafi KuchayAmbrish Mithal
May 31, 2017·Nutrients·Bernd G Stegmayr
Mar 19, 2009·The American Journal of Gastroenterology·Wayne TsuangAndres Gelrud
Jan 24, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Konstantinos P KatopodisKostas C Siamopoulos
Jan 21, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jennifer D Twilla, Jimmie Mancell
Aug 28, 2009·Seminars in Dialysis·Bernd G StegmayrGunilla Olivecrona
Jun 11, 2005·Journal of Applied Physiology·David Ricart-JanéMiquel Llobera
Sep 23, 2009·Current Opinion in Lipidology·Nils EwaldHans-Ulrich Kloer
Dec 7, 2007·American Journal of Physiology. Endocrinology and Metabolism·Rikke Krogh-MadsenBente Klarlund Pedersen
Dec 1, 2011·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Eric W SchaeferNeil J Stone
Apr 9, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Heike ZeitlerChristian P Strassburg
Apr 17, 2015·Journal of Clinical Pharmacology·Bing-Bing YangBirgitta Olsson
Aug 28, 2018·BioMed Research International·Rajat Garg, Tarun Rustagi
Jun 21, 2018·Clinical Journal of Gastroenterology·Prashanth RawlaVinaya Gaduputi
Jan 22, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Noémi ZádoriPéter Hegyi
Jun 24, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Allison L Yang, Julia McNabb-Baltar
May 1, 2021·Life·Carlo Maria BarbagalloEmilio Nardi
Dec 26, 2001·The Journal of Laboratory and Clinical Medicine·D Ng

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

The American Journal of Emergency Medicine
Nasser MikhailDennis Cope
The International Journal of Artificial Organs
Dana MahmoodBernd G Stegmayr
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
T BaranowskiM Fasshauer
© 2021 Meta ULC. All rights reserved