PMID: 15253101Jul 16, 2004Paper

Lipoprotein lipase gene polymorphisms and blood pressure levels in the Northern Chinese Han population

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Biao LiRunsheng Chen

Abstract

The lipoprotein lipase (LPL) gene has been investigated extensively in linkage studies and in studies of its association with lipid profiles and coronary artery disease (CAD), and this gene has also been reported to have an association with hypertension. In our previous linkage study on 148 Chinese hypertensive families, the regions at or near the LPL gene were found to be associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Thus the LPL gene is a logical candidate gene for involvement in the underlying cause of essential hypertension (EH). In the present study, we identified 22 sequence variants by directly sequencing 10 exons and flanking regions of the LPL gene, and investigated the occurrence of 3 of these variants, IVS4-214C>T, 7754C>A and S447X, in a case-control study including 501 normotensive (NT) subjects and 497 EH subjects. In males, the frequencies of the genotypes of each of the 3 variants did not differ significantly between the NT and EH groups. Among the EH group in females, ANCOVA revealed no significant difference in blood pressure levels according to the 7754C>A genotype. However, in female, the distribution of the 7754C>A genotype and the frequency of the A allele of 7754C>A dif...Continue Reading

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Jan 1, 1996·Pharmacology & Therapeutics·V MurthyC Gagne
Jul 14, 1998·Nature Genetics·D A NickersonC F Sing
Apr 1, 1999·Journal of Hypertension·J A StaessenR Fagard
Apr 1, 1999·Journal of Hypertension·S C HuntM F Leppert
Apr 21, 2001·European Journal of Human Genetics : EJHG·J AkeyM Xiong
Jun 19, 2001·American Journal of Human Genetics·J K Pritchard
Oct 5, 2001·Nature Genetics·M J DalyE S Lander
Oct 5, 2001·Nature Genetics·G C JohnsonJ A Todd
Dec 13, 2001·American Journal of Human Genetics·Tianhua NiuJun S Liu
May 4, 2002·Nature Reviews. Genetics·Holly K TaborRichard M Myers
Nov 1, 2002·Journal of Hypertension·Olle Melander
Dec 7, 2002·Hypertension·Dongfeng GuUNKNOWN InterASIA Collaborative Group. The International Collaborative Study of Cardiovascular Disease in ASIA
Feb 8, 2003·Hypertension·Buaijiaer HasimuYukio Ozawa
Jul 17, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoru MurayamaMitsuru Adachi

❮ Previous
Next ❯

Citations

Mar 1, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Yan ShenGuang-Biao Zhou
Nov 6, 2008·Experimental & Molecular Medicine·Yoon Shin ChoBermseok Oh
Aug 30, 2008·The American Journal of Medicine·Yin RuixingChen Yuming
Nov 12, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Lucia Maria ProcopciucGabriela Caracostea
Apr 1, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jaap RipJan Albert Kuivenhoven
Sep 5, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Na LiuXiaoming Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.