PMID: 7538426Mar 1, 1995Paper

Lipoprotein lipase synergizes with interferon gamma to induce macrophage nitric oxide synthetase mRNA expression and nitric oxide production

Arteriosclerosis, Thrombosis, and Vascular Biology
G Renier, A Lambert

Abstract

Lipoprotein lipase (LPL) induces macrophage tumor necrosis factor-alpha (TNF-alpha) gene expression and protein secretion. Since TNF-alpha can increase interferon gamma (IFN-gamma)-dependent nitric oxide (NO) production, we studied whether LPL may synergize with IFN-gamma for the induction of macrophage NO production. Although ineffective by itself, LPL in combination with IFN-gamma increased L-arginine-dependent NO production in a dose-dependent manner. Preincubation of LPL with an anti-LPL neutralizing antibody totally suppressed this effect. Increased NO synthetase (NOS) mRNA expression was also observed after macrophage treatment with IFN-gamma and LPL. Protein synthesis was required for the induction of NOS mRNA, and a TNF-alpha-mediated effect of LPL on NOS gene expression and NO production was observed. The ability of LPL to augment IFN-gamma-dependent NOS mRNA expression was associated with an increase in the NOS gene transcriptional activity but not in the NOS mRNA stability. Finally, binding of nuclear proteins to the nuclear factor-kappa B- and TNF-alpha-responsive sequences of the macrophage NOS promotor was decreased by treatment of the cells by IFN-gamma alone or in combination with LPL. These data provide evidenc...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Investigation·S C RumseyI J Goldberg
Jan 1, 1992·Metabolism: Clinical and Experimental·T J Yost, R H Eckel
Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D J StuehrC F Nathan
Dec 19, 1986·Biochimica Et Biophysica Acta·S R Behr, F B Kraemer
Apr 20, 1989·The New England Journal of Medicine·R H Eckel
Oct 1, 1987·The Journal of Clinical Investigation·R H Eckel, T J Yost
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Nov 30, 1984·Biochemical and Biophysical Research Communications·T OkabeF Takaku
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R H Eckel, R J Robbins
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C J LowensteinW J Murphy

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Citations

Jun 15, 1997·Biochemical Pharmacology·H JikiharaA M Poisner
Nov 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kent D TaylorJerome I Rotter
Oct 12, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Chuchun L ChangRichard J Deckelbaum
Oct 29, 2005·Metabolism: Clinical and Experimental·Melchior C NiermanErik S G Stroes
Dec 2, 1999·FEBS Letters·J R MeadD P Ramji
Jul 8, 2008·Journal of Atherosclerosis and Thrombosis·Takashi HitsumotoKohji Shirai
Mar 10, 2007·Molecular Biology Reports·Jizhong LuShengdong Huang
Oct 31, 2006·World Journal of Gastroenterology : WJG·Toshihito KosakaTakahiko Katoh
Aug 10, 2016·European Journal of Haematology·Ans RomboutJan Philippé
Sep 20, 2005·Journal of the American College of Cardiology·Pascalle S MonraatsJ Wouter Jukema

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