Lipoprotein oxidation, antioxidants and cardiovascular risk: epidemiologic evidence

Prostaglandins, Leukotrienes, and Essential Fatty Acids
L P van de VijverG van Poppel

Abstract

This review summarizes the scientific evidence for a possible role of antioxidants in the prevention of coronary heart disease (CHD). Dietary antioxidants include vitamin E, vitamin C and beta-carotene, whereas selenium is an integral part of the antioxidant enzyme glutathione peroxidase. Experimental studies suggest that the oxidation of low-density lipoproteins (LDL) in the vessel wall plays an important role in the development of atherosclerotic lesions. The resistance of LDL to oxidation is increased by antioxidant supplementation, at least in vitro. Epidemiological studies have not demonstrated unequivocally that a high intake of antioxidants leads to a decreased risk of CHD. Studies on dietary intake and serum levels of antioxidants do point in the direction of a preventive effect of antioxidants, whereas the results of intervention studies are less conclusive. Beta-carotene supplementation is not associated with any decrease in CHD; high doses of vitamin E may be beneficial, but results from large trials are to be awaited. General preventive measures based on antioxidant supplementation are not yet justifiable.

References

Sep 30, 1992·Annals of the New York Academy of Sciences·I Jialal, S M Grundy
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Jan 1, 1991·The American Journal of Clinical Nutrition·D L Trout
Mar 1, 1991·The American Journal of Clinical Nutrition·D W NierenbergT A Stukel
Mar 1, 1991·The American Journal of Clinical Nutrition·T V RingerG S Hughes
Mar 24, 1990·BMJ : British Medical Journal·A GramenziC La Vecchia
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S ParthasarathyD Steinberg
Feb 4, 1989·BMJ : British Medical Journal·M D StringerV V Kakkar
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Jan 1, 1989·European Journal of Clinical Pharmacology·J KleijnenG ter Riet
Feb 24, 1989·JAMA : the Journal of the American Medical Association·F J KokH A Valkenburg
Feb 1, 1989·Annals of Medicine·J T Salonen
Jan 1, 1988·Free Radical Biology & Medicine·B Hennig, C K Chow
May 1, 1987·The American Journal of Clinical Nutrition·K F GeyH B Stähelin
Jun 1, 1987·International Journal of Epidemiology·J T Salonen
Feb 1, 1987·The American Journal of Clinical Nutrition·F J KokH A Valkenburg
Aug 1, 1985·American Journal of Epidemiology·J VirtamoM J Karvonen
May 11, 1984·Science·G W Burton, K U Ingold
Dec 15, 1995·American Journal of Epidemiology·D K PandeyJ Stamler
Oct 1, 1995·The Journal of Clinical Investigation·A ShaishJ W Heinecke
Mar 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·H M PrincenV W van Hinsbergh
Jun 21, 1995·JAMA : the Journal of the American Medical Association·H N HodisS P Azen
Oct 1, 1994·Current Opinion in Lipidology·A Chait, J W Heinecke
Mar 1, 1995·American Journal of Epidemiology·A F KardinaalR J Hermus
Nov 9, 1994·JAMA : the Journal of the American Medical Association·D L MorrisC E Davis

❮ Previous
Next ❯

Citations

Jul 24, 2003·Journal of the American College of Cardiology·Stavroula K OsganianWalter C Willett
Nov 13, 2004·The Journal of Nutritional Biochemistry·W R LeifertE J McMurchie
May 1, 2013·Journal of Agricultural and Food Chemistry·Yuge NiuLiangli Lucy Yu
Dec 16, 1998·The British Journal of Nutrition·G HornstraP M Verschuren
Aug 25, 2001·The British Journal of Nutrition·F BrancaH Verhagen
Jun 23, 2005·Critical Reviews in Food Science and Nutrition·John ShiYueming Jiang
Oct 27, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·François Nsemi MuandaAmadou Dicko
May 11, 2002·Environmental Health Perspectives·Jean-François LesgardsMarie-Pascale Lehucher-Michel
Aug 10, 2000·Drugs·P H Chong, B S Bachenheimer
Dec 4, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)· MutakinHiroshi Koyama
Nov 29, 2005·Molecular Aspects of Medicine·Norman I Krinsky, Elizabeth J Johnson
Aug 26, 1998·Biochemical and Biophysical Research Communications·A DuringJ C Smith
Jun 4, 2011·Toxicology and Industrial Health·Dilek YilmazRahmi Bilaloglu
Mar 17, 2000·Circulation Research·L MoldovanP J Goldschmidt-Clermont
Apr 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Neda Mimica-DukićMaria Couladis
Aug 25, 2001·The British Journal of Nutrition·H CrewsG Williamson
Jun 7, 2003·The American Journal of Clinical Nutrition·Stavroula K OsganianWalter C Willett
Dec 5, 1998·Nutrition Reviews·R A Jacob
Apr 29, 2004·Journal of Agricultural and Food Chemistry·Neda Mimica-DukicNatasa Simin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.