Abstract
A cohort of young families from Tallinn was studied for coronary risk factors. In sera from 239 adults and cord blood from 138 of their newborns, TC, HDL-C, LDL-C, TG, Lp(a) and apo-B levels were determined, and body mass index (BMI) and lifestyle factors were registered. In newborns, characteristics of maturity were assessed by Dubowitz and Apgar scores after birth. The aim of the study was to investigate the risk factors for atherosclerosis in young families and to reveal the main determinants of atherogenic lipoprotein parameters in adults and newborns. Using the criteria of the International Lipid Information Bureau, it was found that 24.4% of the men and 9.8% of the women were hypercholesterolemic, 31.5% of the men and 9.6% of the women had low HDL-C, TG levels were elevated accordingly in 5.3% and 1.2% of subjects. The independent determinants of TG level in males were BMI and age, and for LDL-C and apo-B levels--BMI, age and nationality. Female neonates had higher TC, HDL-C and apo-B levels than male neonates, the differences seeming to be associated with the different physiological requirements of male and female fetuses. Newborns' HDL-C levels were correlated positively with their TCs (r=0.72; p<0.001), LDL-C (r=0.47; ...Continue Reading
References
Jul 1, 1992·The Journal of Clinical Investigation·E BoerwinkleH H Hobbs
May 1, 1992·Acta Paediatrica·P ValdivielsoM V Martínez-Guerrero
Jan 1, 1991·Biology of the Neonate·M R AvernaA Notarbartolo
Oct 1, 1986·Circulation·G H DahlenA M Gotto
Apr 1, 1988·Pediatric Research·C R ParkerJ C Hauth
Nov 1, 1987·Scandinavian Journal of Clinical and Laboratory Investigation·P RiepponenT Rautaoja
Apr 1, 1966·Analytical Biochemistry·C B Laurell
Jul 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·D J MoliternoH H Hobbs
Apr 1, 1996·Acta Paediatrica·T RoutiO Simell
Dec 1, 1996·European Heart Journal·L BraeckmanG De Backer
Jul 10, 1999·Scandinavian Journal of Clinical and Laboratory Investigation·K AasveeC Ehnholm
Dec 2, 1999·Atherosclerosis·C M LoughreyN Rifai
Oct 12, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·D M LaneM Hall
Citations
Nov 21, 2014·European Journal of Nutrition·Eva GesteiroFrancisco J Sánchez-Muniz
May 23, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·K AasveeA Baburin
Nov 8, 2005·Scandinavian Journal of Clinical and Laboratory Investigation·E KurvinenJ Sundvall
Jul 5, 2016·Journal of Physiology and Biochemistry·Paloma CeladaBegoña Olmedilla-Alonso
Nov 30, 2007·Pediatric Cardiology·Zohreh Badiee, Roya Kelishadi
Apr 27, 2011·Journal of Cardiovascular Medicine·Silvia BarraMaurizio Trevisan
Feb 16, 2013·European Journal of Pediatrics·Eva GesteiroFrancisco J Sánchez-Muniz
Oct 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Nina StrandkjærPia R Kamstrup