Lipoprotein parameters in relation to other risk factors of atherosclerosis in adults and newborns: Tallinn Young Family Study

Scandinavian Journal of Clinical and Laboratory Investigation
K AasveeJ Sundvall

Abstract

A cohort of young families from Tallinn was studied for coronary risk factors. In sera from 239 adults and cord blood from 138 of their newborns, TC, HDL-C, LDL-C, TG, Lp(a) and apo-B levels were determined, and body mass index (BMI) and lifestyle factors were registered. In newborns, characteristics of maturity were assessed by Dubowitz and Apgar scores after birth. The aim of the study was to investigate the risk factors for atherosclerosis in young families and to reveal the main determinants of atherogenic lipoprotein parameters in adults and newborns. Using the criteria of the International Lipid Information Bureau, it was found that 24.4% of the men and 9.8% of the women were hypercholesterolemic, 31.5% of the men and 9.6% of the women had low HDL-C, TG levels were elevated accordingly in 5.3% and 1.2% of subjects. The independent determinants of TG level in males were BMI and age, and for LDL-C and apo-B levels--BMI, age and nationality. Female neonates had higher TC, HDL-C and apo-B levels than male neonates, the differences seeming to be associated with the different physiological requirements of male and female fetuses. Newborns' HDL-C levels were correlated positively with their TCs (r=0.72; p<0.001), LDL-C (r=0.47; ...Continue Reading

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Citations

Nov 21, 2014·European Journal of Nutrition·Eva GesteiroFrancisco J Sánchez-Muniz
May 23, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·K AasveeA Baburin
Nov 8, 2005·Scandinavian Journal of Clinical and Laboratory Investigation·E KurvinenJ Sundvall
Jul 5, 2016·Journal of Physiology and Biochemistry·Paloma CeladaBegoña Olmedilla-Alonso
Nov 30, 2007·Pediatric Cardiology·Zohreh Badiee, Roya Kelishadi
Oct 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Nina StrandkjærPia R Kamstrup

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