PMID: 6405728May 1, 1983Paper

Lipoprotein profiles in rhesus monkeys with divergent responses to dietary cholesterol

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
H N BakerJ P Strong

Abstract

From a group of 53 rhesus monkeys, we selected 12 animals, the six with the highest and the six with the lowest response to a high cholesterol diet, and we made detailed analyses of their cholesterol and apolipoprotein profile. The high responders differed from the low responders in several ways. During the high cholesterol diet period, the high responders had much higher plasma apolipoprotein B and E concentrations and much lower plasma apolipoprotein A-I concentrations than did the low responders. Nearly all the increase in plasma cholesterol and apolipoproteins B and E concentrations in the high responders occurred in the lower density fractions (d = 1.006-1.030 g/ml), while the decrease in plasma apolipoprotein A-I concentrations in the high responders was confined to the lower density fraction of the high density lipoproteins (HDL), i.e., HDL2 (d = 1.063-1.125 g/ml). In the low responders, on the other hand, the slight increase in cholesterol concentrations was evenly distributed between the lower density fractions and HDL, and the increase in apolipoprotein A-I concentration of the lower density fractions is related to the decrease in the concentration in the HDL2 in the high responders.

Citations

Jan 1, 1997·Progress in Cardiovascular Diseases·G R De Meyer, A G Herman
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G W Melchior, C K Castle
May 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A K BhattacharyyaJ P Strong
Feb 1, 1990·Circulation·P D Henry
Aug 17, 2019·EvoDevo·Katherine C Woronowicz, Richard A Schneider
Aug 1, 1987·Experimental and Molecular Pathology·H N Baker, C R Abee
Feb 12, 1986·The American Journal of Cardiology·P S Roheim
Dec 1, 1985·Atherosclerosis·G W MelchiorM T Brandon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.