Lipoprotein subfractions and dietary intake of n-3 fatty acid: the Genetics of Coronary Artery Disease in Alaska Natives study.

The American Journal of Clinical Nutrition
Giovanni AnnuzziBarbara V Howard

Abstract

Few studies have compared lipoprotein composition with dietary intake. The lipoprotein subfraction profile was evaluated in relation to diet in Alaska Eskimos at high cardiovascular risk but with a low frequency of hyperlipidemia and high intake of n-3 (omega-3) fatty acids. A population-based sample (n = 1214) from the Norton Sound Region of Alaska underwent a physical examination and blood sampling. Analyses were from 977 individuals who did not have diabetes or use lipid-lowering medications and had complete dietary information (food-frequency questionnaire) and a lipoprotein subfraction profile (nuclear magnetic resonance spectroscopy). After adjustment for age, BMI, total energy intake, and percentage of energy from fat, the intake of n-3 fatty acids was significantly associated with fewer large VLDLs (P = 0.022 in women, P = 0.064 in men), a smaller VLDL size (P = 0.018 and P = 0.036), more large HDLs (P = 0.179 and P = 0.021), and a larger HDL size (P = 0.004 and P = 0.001). After adjustment for carbohydrate and sugar intakes, large VLDLs (P = 0.042 and 0.018) and VLDL size (P = 0.011 and 0.025) remained negatively associated with n-3 fatty acid intake in women and men, and large HDLs (P = 0.067 and 0.005) and HDL size (...Continue Reading

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May 29, 2015·Molecular Nutrition & Food Research·Doris M JacobsJohn van Duynhoven
Jan 22, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L H BoglJ Kaprio
Feb 28, 2020·Journal of the American Heart Association·Nuria AmigóSamia Mora
Feb 6, 2021·Current Atherosclerosis Reports·Jan Pitha, Rudolf Poledne

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