PMID: 18407156Aug 1, 1993Paper

Lipoprotein-thyroid hormone interactions

Trends in Endocrinology and Metabolism : TEM
S Benvenga, J Robbins

Abstract

A small but significant portion of the thyroid hormones that circulate in human plasma is associated with lipoproteins. Although the major lipoprotein carrier is HDL, the role of these interactions on T(4) entry into cells was tested first with LDL and human fibroblasts because of the well-characterized LDL receptors and the availability of cells with genetically absent receptors. It was shown that LDL enhanced the uptake of T(4) by cultured fibroblasts in which the LDL receptors were expressed. The T(4) binding sites on apolipoproteins B-100 and E, as well as apoA-I, have been partially characterized, and they exhibit considerable homology. A number of possible physiologic consequences of thyroid hormonelipoprotein interactions have been put forward as topics for further investigation.

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Citations

Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson
Aug 24, 2002·Thyroid : Official Journal of the American Thyroid Association·Salvatore BenvengaFrancesco Trimarchi
May 30, 2002·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·S BenvengaJ Robbins
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Gerhard Schreiber
Jun 16, 2001·Journal of Endocrinological Investigation·S BenvengaF Trimarchi
Mar 9, 2002·Journal of Endocrinological Investigation·S BenvengaF Trimarchi
Mar 17, 2007·Critical Reviews in Toxicology·Douglas J FortLeslie W Touart
Jan 6, 2018·International Journal of Molecular Sciences·Assim A AlfaddaAishah A Ekhzaimy
Dec 1, 1996·Thyroid : Official Journal of the American Thyroid Association·S Benvenga, J Robbins
Aug 9, 2003·Journal of Endocrinological Investigation·L H Duntas

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