Lipoprotein transport in the metabolic syndrome: pathophysiological and interventional studies employing stable isotopy and modelling methods

Clinical Science
Dick C ChanGerald F Watts

Abstract

The accompanying review in this issue of Clinical Science [Chan, Barrett and Watts (2004) Clin. Sci. 107, 221-232] presented an overview of lipoprotein physiology and the methodologies for stable isotope kinetic studies. The present review focuses on our understanding of the dysregulation and therapeutic regulation of lipoprotein transport in the metabolic syndrome based on the application of stable isotope and modelling methods. Dysregulation of lipoprotein metabolism in metabolic syndrome may be due to a combination of overproduction of VLDL [very-LDL (low-density lipoprotein)]-apo (apolipoprotein) B-100, decreased catabolism of apoB-containing particles and increased catabolism of HDL (high-density lipoprotein)-apoA-I particles. These abnormalities may be consequent on a global metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, that collectively increases the flux of fatty acids from adipose tissue to the liver, the accumulation of fat in the liver and skeletal muscle, the hepatic secretion of VLDL-triacylglycerols and the remodelling of both LDL (low-density lipoprotein) and HDL particles in the circulation. These lipoprotein defects are also related to perturbations in both lipo...Continue Reading

References

Aug 1, 1992·The American Journal of Clinical Nutrition·A M Dattilo, P M Kris-Etherton
Jul 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·C BaynesR S Elkeles
Apr 1, 1991·European Journal of Clinical Investigation·J D BagdadeP V Subbaiah
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H J KempenL M Havekes
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Apr 20, 1989·The New England Journal of Medicine·R H Eckel
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Jan 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R B TerryR M Krauss
May 1, 1985·The Journal of Clinical Investigation·K SakuM L Kashyap
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J R PatschA M Gotto
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·L LagrostP Gambert
May 13, 1994·Biochimica Et Biophysica Acta·Z Yao, R S McLeod
Jul 1, 1993·The American Journal of Clinical Nutrition·W S Harris, F Muzio
May 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A D Sniderman, K Cianflone
May 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M J CaslakeJ Shepherd
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
May 1, 1997·The American Journal of Clinical Nutrition·W S Harris
Jun 1, 1997·Current Opinion in Lipidology·G F Lewis
Jun 1, 1997·Current Opinion in Lipidology·A RigottiM Krieger
Jan 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·C J Packard, J Shepherd
Jun 11, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F M RichesG R Thompson

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Citations

Jul 26, 2008·Plant Foods for Human Nutrition·Mian-Ying WangJarakae Jensen
Jan 13, 2006·Current Opinion in Lipidology·Dick C ChanGerald F Watts
Jan 15, 2011·Current Opinion in Lipidology·Srinivasa P Munigoti, Alan Rees
Dec 4, 2009·PLoS Computational Biology·Albert A de GraafBen van Ommen
May 11, 2010·Atherosclerosis. Supplements·Gerald F Watts, Dick C Chan
Jun 6, 2009·Pharmacology & Therapeutics·Gerald F WattsDick C Chan
Apr 1, 2009·Journal of Clinical Lipidology·Sunita DodaniSunil Joshi
Dec 7, 2011·Journal of Internal Medicine·J BorénM Adiels
Nov 30, 2006·Biochemical and Biophysical Research Communications·Markus NeumeierChrista Buechler
Feb 13, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Dick C ChanP Hugh R Barrett
Jan 18, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Dick C ChanP Hugh R Barrett
Nov 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Caroline RichardBenoît Lamarche
Jan 3, 2015·Endocrine Reviews·Gary F LewisRobert A Hegele
Nov 9, 2007·Surgical and Radiologic Anatomy : SRA·Nihal ApaydinR Shane Tubbs
Jan 29, 2016·Science Translational Medicine·Gissette Reyes-SofferHenry N Ginsberg
May 8, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sjoerd A A van den BergKo Willems van Dijk
Jul 16, 2010·Expert Opinion on Pharmacotherapy·Dick C Chan, Gerald F Watts
Nov 3, 2016·Current Opinion in Lipidology·Dick C ChanGerald F Watts

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