Lipoprotein(a) and Cardiovascular Risk Prediction Among Women

Journal of the American College of Cardiology
Nancy R CookPaul M Ridker

Abstract

Although lipoprotein(a) [Lp(a)] is associated with incident cardiovascular disease (CVD), its contribution to prediction remains controversial. This study examined the association and clinical utility of Lp(a) with incident CVD in women. A turbidimetric assay assessed Lp(a) in 3 cohorts of women (the WHS [Women's Health Study] [N = 24,558], a case-cohort sample from the WHI [Women's Health Initiative] Observational Study [n = 1,815 cases, subcohort n = 1,989], and the JUPITER [Justification for Use of Statins in Prevention] trial [n = 2,569]) and in men from JUPITER (n = 5,161). A WHS derivation sample (n = 16,400) determined the form of association with incident CVD. This was tested in WHS validation data (n = 8,158) and the other study samples. Models including traditional CV risk factors but with and without Lp(a) were compared using risk reclassification. In the WHS, there was a curvilinear association, with increased CVD risk among those with Lp(a) >50 mg/dl, but only among women with total cholesterol (TC) >220 mg/dl. In the WHS test sample, there was a small but significant change in the C-statistic (0.790 to 0.797; p = 0.035) but no improvement in measures of reclassification. This pattern was replicated among women in ...Continue Reading

Citations

Feb 6, 2019·Current Opinion in Lipidology·Ernst J SchaeferGregory Endress
May 27, 2020·Cardiology and Therapy·Keon Pearson, Fatima Rodriguez
Sep 24, 2020·Molecular and Cellular Biochemistry·V S Jayalekshmi, Surya Ramachandran
Nov 7, 2019·Cardiology in Review·Perry Mayo-Malasky, William H Frishman
Dec 1, 2019·Journal of Clinical Medicine·Natalie C WardGerald F Watts
Sep 11, 2019·European Heart Journal·François MachUNKNOWN ESC Scientific Document Group
Aug 22, 2020·Journal of Lipid and Atherosclerosis·Seonghoon Choi
Aug 2, 2019·Current Cardiology Reports·Nestor Vasquez, Parag H Joshi
Oct 24, 2019·European Journal of Preventive Cardiology·Marco GentilePaolo Rubba
Sep 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Connie B NewmanLisa R Tannock
Nov 26, 2020·Clinical Chemistry·Pia R Kamstrup
Dec 18, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Federico BigazziTiziana Sampietro
Oct 9, 2019·Atherosclerosis·UNKNOWN Authors/Task Force MembersUNKNOWN ESC National Cardiac Societies
Dec 10, 2019·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Ángel Díaz Rodríguez, Teresa Mantilla Morató
Apr 28, 2020·The American Journal of Cardiology·Nishant P ShahManesh R Patel
Apr 27, 2021·Practical Laboratory Medicine·Sara P Wyness, Jonathan R Genzen
Jun 20, 2021·Current Atherosclerosis Reports·Anum SaeedSalim S Virani
Jul 21, 2021·Nutrición hospitalaria·Aina Tomás LuizMaría Jesús Periago

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