Lipoprotein(a) and ischemic heart disease--a causal association? A review

Atherosclerosis
Pia R Kamstrup

Abstract

The aim of this review is to summarize present evidence of a causal association of lipoprotein(a) with risk of ischemic heart disease (IHD). Evidence for causality includes reproducible associations of a proposed risk factor with risk of disease in epidemiological studies, evidence from in vitro and animal studies in support of pathophysiological effects of the risk factor, and preferably evidence from randomized clinical trials documenting reduced morbidity in response to interventions targeting the risk factor. Elevated and in particular extreme lipoprotein(a) levels have in prospective studies repeatedly been associated with increased risk of IHD, although results from early studies are inconsistent. Data from in vitro and animal studies implicate lipoprotein(a), consisting of a low density lipoprotein particle covalently bound to the plasminogen-like glycoprotein apolipoprotein(a), in both atherosclerosis and thrombosis, including accumulation of lipoprotein(a) in atherosclerotic plaques and attenuation of t-PA mediated plasminogen activation. No randomized clinical trial of the effect of lowering lipoprotein(a) levels on IHD prevention has ever been conducted. Lacking evidence from randomized clinical trials, genetic studi...Continue Reading

References

Oct 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C SandholzerG Utermann
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J LoscalzoA M Scanu
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M RathU Beisiegel
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·L B NielsenK Kjeldsen
Mar 1, 1995·The Journal of Clinical Investigation·D J RaderM Grossman
Jul 1, 1993·Human Molecular Genetics·C LacknerH H Hobbs
Apr 1, 1996·Circulation Research·L B NielsenB G Nordestgaard
Jun 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·H G KraftG Utermann
Dec 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·F KronenbergG Utermann
May 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·L B NielsenB G Nordestgaard
Mar 21, 1998·Journal of the American College of Cardiology·B CantinG R Dagenais
Oct 22, 1998·European Journal of Human Genetics : EJHG·A LingenhelG Utermann
Dec 5, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S AllenM Yacoub
Feb 6, 1999·Journal of the American College of Cardiology·C GazzarusoD Geroldi
Apr 19, 2000·JAMA : the Journal of the American Medical Association·M G ShlipakS B Hulley

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Citations

Aug 6, 2013·Cardiovascular Drugs and Therapy·Amirhossein Sahebkar, Gerald F Watts
Mar 4, 2011·Current Atherosclerosis Reports·S SivapalaratnamG M Dallinga-Thie
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Pia R Kamstrup, Børge G Nordestgaard
Jul 14, 2011·Metabolic Syndrome and Related Disorders·Byambaa EnkhmaaLars Berglund
Feb 14, 2012·Current Opinion in Lipidology·Joseph B DubéMarlys L Koschinsky
May 5, 2011·Journal of Cardiovascular Medicine·Anna PatrignaniNino Ciampani
Aug 12, 2015·The American Journal of the Medical Sciences·Kwang Jin ChoiConstantine E Kosmas
Oct 16, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T BradleyA E Hughes
Oct 9, 2012·Metabolism: Clinical and Experimental·Jane Hoover-Plow, Menggui Huang
Dec 31, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Anders HovlandKnut Tore Lappegård
May 27, 2011·Journal of Clinical Lipidology·Jennifer G RobinsonUNKNOWN National Lipid Association Expert Panel on Familial Hypercholesterolemia
Jan 27, 2012·Journal of Clinical Pharmacy and Therapeutics·G Lippi, G Targher
Nov 9, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T TzotzasD N Kiortsis
Apr 12, 2016·Atherosclerosis·C SchmöckerK H Weylandt
Mar 19, 2014·Atherosclerosis·Anne LangstedBørge G Nordestgaard
Aug 1, 2015·Journal of Clinical Lipidology·Konstantin A KrychtiukWalter S Speidl
Oct 29, 2013·Journal of the American College of Cardiology·Pia R KamstrupBørge G Nordestgaard
May 6, 2015·Atherosclerosis. Supplements·Wolfram C PollerKathrin Enke-Melzer
Feb 5, 2013·Journal of the American College of Cardiology·Pia R KamstrupBørge G Nordestgaard
Sep 11, 2012·Molecular Genetics and Metabolism·Tommaso FasanoSebastiano Calandra
Nov 20, 2013·Disease Markers·Anping CaiYingling Zhou
May 14, 2016·Critical Reviews in Clinical Laboratory Sciences·Kazuhiko KotaniMaciej Banach
Nov 9, 2016·Journal of Lipid Research·Karam M Kostner, Gert M Kostner
Nov 3, 2016·Journal of Lipid Research·Børge G Nordestgaard, Anne Langsted
Oct 19, 2010·Journal of Psychopharmacology·Georgios PaslakisMichael Deuschle
Jun 3, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Pia R KamstrupBørge G Nordestgaard
Apr 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Pia R KamstrupBørge G Nordestgaard
Oct 20, 2011·Circulation. Cardiovascular Genetics·Yonghong LiJames J Devlin
Feb 13, 2019·Nutrients·Karsten-H WeylandtUrsula Kassner
Jan 15, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Pia R KamstrupBørge G Nordestgaard

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