Lipoprotein(a) and livedoid vasculopathy: A new thrombophilic factor?

Medical Hypotheses
Paulo Ricardo CriadoMirian Nacagami Sotto

Abstract

Livedoid vasculopathy is a chronic disorder characterised by recurrent reticulated purpura on lower extremities, associated with painful purpuric or necrotic macules and ulcerations. Current knowledge indicates LV to be a thrombo-occlusive vasculopathy of cutaneous blood vessels; exact pathogenesis is yet to be understood. Elevated levels of lipoprotein(a) have been found in LV patients. To date, elevated plasma levels of lipoprotein(a) are considered an independent and causal genetic risk factor for the development of cardiovascular disease, as well as a relevant factor in hypercoagulable states. Because of its structural homology with plasminogen, Lp(a) might have important anti-fibrinolytic properties. Altered endothelial function and participation in immune and autoimmune processes, such as antiphospholipid syndrome, are also potential mechanisms of Lp(a) involvement in LV pathogenesis. Lp(a) is part of the wound healing process; the possibility of Lp(a) serum elevation to reflect an acute-phase reagent in LV scenario is also considered. The objective of this review is to examine the possible association of lipoprotein(a) with LV pathogenesis, based on its effects on thrombogenesis, fibrinolysis and autoimmunity.

References

Jan 1, 1994·Chemistry and Physics of Lipids·A NomaK Shimokawa
Apr 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Y YanoA Noma
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·G H Hsiao, H C Chiu
Jan 20, 1999·The British Journal of Dermatology·S H WakelinM M Black
Apr 24, 1999·The British Journal of Dermatology·K M AclandR Russell-Jones
Sep 30, 2005·Acta Dermato-venereologica·Christian HafnerThomas Vogt
Feb 13, 2007·Clinical Biochemistry·Mirjana BećarevićNada Majkić-Singh
Jan 22, 2008·Hematology/oncology Clinics of North America·Sari Weinstein, Warren Piette
Nov 26, 2008·Circulation·Mark Y ChanRichard C Becker
Oct 31, 2009·Clinical and Experimental Dermatology·S KheniferS Dalle
Jan 16, 2010·The American Journal of Dermatopathology·Pa-Fan Hsiao, Yu-Hung Wu
Mar 27, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·T B Di GiacomoP R Criado
Dec 25, 2010·International Journal of Dermatology·Su-ying FengChang-geng Shao
Dec 28, 2010·Autoimmunity Reviews·Paulo Ricardo CriadoJozélio Freire de Carvalho
Jan 12, 2011·The British Journal of Dermatology·R VasconcelosW Belda
Feb 12, 2011·Journal of Thrombosis and Thrombolysis·Mehmet AgirbasliDouglas E Vaughan
Aug 2, 2011·Journal of Proteomics·Anne von ZychlinskiSally P McCormick
Oct 11, 2011·Journal of the American Academy of Dermatology·Chih-Hsun YangWan-Jing Ho
Nov 15, 2011·La Revue de médecine interne·C FrancèsA Soria
Jun 30, 2012·Dermatologic Therapy·Tania M Gonzalez-Santiago, Mark D P Davis
Sep 20, 2012·Cholesterol·Kirsten Riches, Karen E Porter
Jan 11, 2013·International Journal of Rheumatology·I MissalaE Steinhagen-Thiessen
Mar 14, 2013·BioMed Research International·Michele MalaguarneraAlessandro Frigiola
Aug 31, 2013·VASA. Zeitschrift für Gefässkrankheiten·Nina Kerk, Tobias Goerge
Sep 14, 2013·Journal of the American Academy of Dermatology·Afsaneh AlaviRobert S Kirsner
Sep 18, 2013·The International Journal of Lower Extremity Wounds·Paulo Ricardo CriadoRobert S Kirsner
Nov 5, 2013·Mayo Clinic Proceedings·Terry A Jacobson

❮ Previous
Next ❯

Citations

Mar 16, 2017·Medicine·Stephen Chu-Sung HuYung-Song Lin
Jul 14, 2020·Reviews in Medical Virology·Paulo Ricardo CriadoJuarez Antonio Simões Quaresma
Jan 23, 2021·JAAD International·See Wei TanChoon Chiat Oh
Nov 6, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marie-Luise SchiffmannTobias Goerge
Nov 24, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marie-Luise SchiffmannTobias Goerge

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.