Lipoprotein(a) in health and disease

Critical Reviews in Clinical Laboratory Sciences
Florian KronenbergHans Dieplinger

Abstract

Lipoprotein(a) [Lp(a)] represents an LDL-like particle to which the Lp(a)-specific apolipoprotein(a) is linked via a disulfide bridge. It has gained considerable interest as a genetically determined risk factor for atherosclerotic vascular disease. Several studies have described a correlation between elevated Lp(a) plasma levels and coronary heart disease, stroke, and peripheral atherosclerosis. In healthy individuals, Lp(a) plasma concentrations are almost exclusively controlled by the apo(a) gene locus on chromosome 6q2.6-q2.7. More than 30 alleles at this highly polymorphic gene locus determine a size polymorphism of apo(a). There exists an inverse correlation between the size (molecular weight) of apo(a) isoforms and Lp(a) plasma concentrations. The standardization of Lp(a) quantification is still an unresolved task due to the large particle size of Lp(a), the presence of two different apoproteins [apoB and apo(a)], and the large size polymorphism of apo(a) and its homology with plasminogen. A working group sponsored by the IFCC is currently establishing a stable reference standard for Lp(a) as well as a reference method for quantitative analysis. Aside from genetic reasons, abnormal Lp(a) plasma concentrations are observed...Continue Reading

References

Jan 1, 1992·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B G Murphy, P T McNamee
Apr 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·L SlungaS Eriksson
Feb 1, 1992·Atherosclerosis·Y F PerombelonB L Knight
Jul 1, 1992·The Journal of Clinical Investigation·E BoerwinkleH H Hobbs
Oct 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·C SandholzerG Utermann
Oct 1, 1992·Diabetes·S M HaffnerM K Gruber
Oct 1, 1992·Journal of Internal Medicine·J TyrrellJ Feely
Oct 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·M A GallH H Parving
Nov 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M CambillauM C Plainfosse
Jan 1, 1992·European Journal of Clinical Pharmacology·L SlungaG H Dahlén
Oct 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·G M Kostner
Feb 29, 1992·BMJ : British Medical Journal·J FeelyT Cooke
Jan 1, 1992·Atherosclerosis·D CrookJ C Stevenson
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H J ParraG Luc
May 15, 1992·The American Journal of Cardiology·G SigurdssonN Sigfusson
Aug 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J MölgaardA G Olsson
Oct 1, 1991·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·W MärzW Gross
May 25, 1991·The American Journal of Cardiology·J GenestE J Schaefer
Jun 1, 1991·Annals of the Rheumatic Diseases·S Rantapää-DahlqvistG Dahlén
Apr 1, 1991·Diabetes Care·S M HaffnerD L Rainwater
Jul 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A D MbewuJ P Miller
Jan 1, 1991·Japanese Journal of Medicine·T TakegoshiH Mabuchi
Sep 21, 1991·BMJ : British Medical Journal·H KapelrudK F Hanssen
May 2, 1988·Biochimica Et Biophysica Acta·I KaràdiE Malle
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P C HarpelT S Parker
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G UtermannE Boerwinkle

❮ Previous
Next ❯

Citations

Jul 29, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A BrandstätterF Kronenberg
Aug 29, 2000·Journal of Clinical Pathology·H J MilionisD P Mikhailidis
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·M O EbesununO O Oladapo
Jun 23, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Helmut Borberg
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Florian KronenbergUlrich Neyer
Jun 11, 2004·Clinical Cardiology·Arjun Deb, Noel M Caplice
Sep 25, 2012·Journal of Internal Medicine·F Kronenberg, G Utermann
Jan 18, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Helmut Borberg
Oct 24, 1998·Endocrinology and Metabolism Clinics of North America·J Davignon, J Genest
Jul 18, 2015·Atherosclerosis·Kazuhiko KotaniUNKNOWN Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group
Nov 21, 2012·Journal of cardiology·Angela E Fanshawe, Michael Ibrahim
Sep 16, 2003·Biochimica Et Biophysica Acta·Christa BuechlerGerd Schmitz
Sep 8, 2004·Expert Review of Cardiovascular Therapy·Florian Kronenberg
Nov 9, 2016·Journal of Lipid Research·Karam M Kostner, Gert M Kostner
Jun 6, 2002·Diabetes, Obesity & Metabolism·R W C Pang, K S L Lam
Oct 7, 2017·ILAR Journal·Laura A CoxJohn L VandeBerg
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·D L RainwaterJ L VandeBerg
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·A NiemeierU Beisiegel
Aug 26, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·D L Rainwater, S M Haffner
Oct 19, 2002·Critical Reviews in Clinical Laboratory Sciences·Laura R BenzaquenNader Rifai
Sep 25, 2007·European Journal of Clinical Investigation·G LippiG C Guidi
Apr 4, 1998·Electrophoresis·E M Lobentanz, H Dieplinger
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Eberhard Ritz, Christoph Wanner
Aug 27, 2003·European Journal of Human Genetics : EJHG·Florian KronenbergGerd Utermann
Feb 24, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·L A Sechi, S De Marchi
Oct 7, 2019·Prague Medical Report·Danica LabudovicSonja Topuzovska
Mar 12, 2003·Critical Reviews in Clinical Laboratory Sciences·Giuseppe Lippi, Giancesare Guidi
Mar 31, 1998·Clinical Genetics·F KronenbergH Dieplinger
Jun 14, 2018·Clinical Science·Allison B ReissJoshua DeLeon
Aug 4, 1999·Current Opinion in Lipidology·H H Hobbs, A L White

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.