PMID: 8963722May 1, 1996Paper

Lipoprotein(a) inhibits collagen-induced aggregation of thrombocytes

Arteriosclerosis, Thrombosis, and Vascular Biology
A GriesG M Kostner

Abstract

Lipoprotein(a) [Lp(a)] is known to interact with human platelets in vitro. In the present study the effect of physiological concentrations of Lp(a) on platelet aggregation was studied. Freshly prepared gel-filtered platelets from healthy donors were incubated for 30 minutes at 37 degrees C with various concentrations of Lp(a); aggregation was triggered with ADP, thrombin, and collagen. Control incubations were performed with Tyrode's solution or LDL. Thrombin- and ADP-triggered aggregations were only slightly influenced by Lp(a), but aggregation of platelets stimulated with collagen (4 micrograms/mL) was markedly inhibited. Measurable effects occurred at low concentrations (0.05 mg/mL) of total Lp(a); at 0.5 mg/mL, maximum aggregation of platelets was inhibited by 54 +/- 20%, and the aggregation rate was attenuated by 47 +/- 19% compared with platelets incubated with Tyrode's solution. Preincubation of collagen (4 micrograms/mL) with Lp(a) yielded similar results. The effect of Lp(a) on platelet aggregation was accompanied by a significant reduction of serotonin release and TXA2 formation. Higher concentrations of collagen ( > or = 10 micrograms/ mL) caused the inhibitory effect on Lp(a) on collagen-induced aggregation to disap...Continue Reading

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Citations

Sep 20, 2012·Cholesterol·Kirsten Riches, Karen E Porter
Aug 1, 2006·Pathophysiology of Haemostasis and Thrombosis·William DiscepoloLars Berglund
Dec 19, 2020·Journal of Psychiatric Research·Nicholas HuiKwok Leung Ong
May 12, 2021·European Journal of Internal Medicine·Peter WohlfahrtJosef Kautzner

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