Lipoproteins and mitogen-activated protein kinase signaling: a role in atherogenesis?

Current Opinion in Lipidology
Iveta DobrevaChristian Widmann

Abstract

Lipoproteins play a critical role in the development of atherosclerosis, which might result partly from their capacity to induce specific intracellular signaling pathways. The goal of this review is to summarize the signaling properties of lipoproteins, in particular, their capacity to induce activation of mitogen-activated protein kinase pathways and the resulting modulation of cellular responses in blood vessel cells. Lipoproteins activate the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in all blood vessel cell types. This may require lipoprotein docking to scavenger receptor B1, allowing transfer of cholesterol and sphingosine-1-phosphate to plasma membranes. Subsequent propagation of the signals probably requires the stimulation of G protein-coupled receptors, followed by the transactivation of receptor tyrosine kinases. Lipoprotein-induced extracellular signal-regulated kinase activity favors cell proliferation, whereas lipoprotein-induced p38 mitogen-activated protein kinase activity leads to cell hyperplasia and promotes cell migration. Some signaling pathways and cellular effects induced by lipoproteins have been observed in atherosclerotic plaques and therefore represent pote...Continue Reading

References

Jan 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M KusuharaB C Berk
Nov 5, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M A DeegE L Bierman
Oct 23, 1997·Current Opinion in Lipidology·J W Heinecke
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·K A RobertsJ C Rutledge
Feb 16, 1999·Biochimica Et Biophysica Acta·Y ZhuM B Stemerman
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M ViñalsL Badimon
Mar 14, 2000·Current Opinion in Cell Biology·J P Incardona, S Eaton
Apr 20, 2000·The Journal of Biological Chemistry·D A Brown, E London
Sep 22, 2000·The Biochemical Journal·S P DaviesP Cohen
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C NapoliW Palinski
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·N OhashiS Sasayama
Apr 5, 2001·Current Atherosclerosis Reports·K S Moulton
Apr 20, 2001·British Journal of Pharmacology·I Gouni-BertholdA Sachinidis
Jul 14, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·Y ZhuM B Stemerman
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Mertens, P Holvoet
Nov 1, 2001·Trends in Cardiovascular Medicine·J L Witztum, D Steinberg
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·David W SteppKirkwood A Pritchard
Jan 4, 2003·The Journal of Biological Chemistry·Chieko MineoPhilip W Shaul
Mar 15, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Shin-ichiro MiuraKeijiro Saku
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien

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Citations

Jun 19, 2007·Biochemistry. Biokhimii︠a︡·E V Dyatlovitskaya
Oct 5, 2011·Journal of the Neurological Sciences·Gianna Ferretti, Tiziana Bacchetti
Sep 2, 2008·Journal of Lipid Research·Natasa BulatChristian Widmann
Nov 22, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fei ChengMichael Torzewski
Dec 7, 2017·Acta Neuropathologica Communications·Maciej JurynczykJacqueline Palace

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