Lipoproteins inhibit platelet aggregation and arachidonic acid metabolism in experimental hypercholesterolaemia

Clinical and Experimental Pharmacology & Physiology
Rukhsana AslamJohn D Connor

Abstract

1. Human plasma contains unidentified components that inhibit arachidonic acid (AA) metabolism. In the present study, we investigated whether plasma from rabbits fed a normal or high-cholesterol diet for 16 weeks also inhibits AA metabolism. Specifically, we studied the effects of plasma on platelet aggregation and on the production of AA metabolites, tri-hydroxyeicosatrienoic acid, 12-hydroxyeicosatetraenoic acid and thromboxane B(2). 2. Haematological and lipid profiles were altered by a high-cholesterol diet. Platelets from hypercholesterolaemic rabbits showed enhanced aggregatory sensitivity to AA and platelet-activating factor. However, plasma from hypercholesterolaemic and control rabbits, when added to the incubation mixture, significantly inhibited platelet aggregation and eicosanoid production. 3. High- and low-density lipoprotein (HDL and LDL, respectively) concentrations increased several-fold in plasma with cholesterol feeding. When added directly to the incubation mixture, both HDL and LDL inhibited platelet aggregation, as well as AA metabolism. 4. Haptoglobin, albumin and Cohn's fraction IV, but not globulins, exhibited antiplatelet and anti-AA metabolism activities. Their concentrations in plasma were not affect...Continue Reading

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Citations

Aug 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sagheer AhmedMarius Moga
Nov 28, 2014·Journal of Translational Medicine·Saima GulMuhammad Zia-Ul-Haq
Jul 7, 2011·Current Opinion in Hematology·Craig N Morrell, Sanjay B Maggirwar

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