Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages

Microbes and Infection
Eri ShimadaTakeshi Igarashi

Abstract

Actinomyces viscosus has been suggested to be associated with periodontal disease. However, the pathogenicity of this bacterium is not known. In this study, we examined inflammation-inducing activity by A. viscosus. Whole cells and a lipophilic fraction of A. viscosus ATCC19246 induced production of interleukin-8 and tumor necrosis factor alpha from both human oral epithelial cells and human monocytoid cells. This cytokine production was blocked by lipoprotein lipase treatment of the lipophilic fraction. In addition, anti-Toll-like receptor 2 antibody blocked the cytokine production. These results suggest that lipoprotein of A. viscosus triggers inflammatory responses in periodontitis by activation of Toll-like receptor 2.

References

Dec 8, 1998·The Journal of Experimental Medicine·C J KirschningM Rothe
Dec 24, 2002·Current Opinion in Immunology·Shizuo Akira
May 10, 2007·Oral Microbiology and Immunology·R KikkertA J van Winkelhoff
Aug 15, 2008·Immunity·Mi Sun Jin, Jie-Oh Lee

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Citations

Jan 22, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Qi WangHaiyang Yu
Sep 2, 2015·International Journal of Medical Microbiology : IJMM·Paul VielkindCatalina-Suzana Stingu
Nov 23, 2013·Pathogens and Disease·Hideo KataokaHirotaka Kuwata
Mar 1, 2016·Oral Diseases·B SongL Q Shao
May 17, 2018·PloS One·Claire WillmannCatherine Thèves
Nov 21, 2018·PloS One·Tatiana Ramirez-MoraGrettel Valle-Bourrouet
Feb 14, 2019·Proceedings of the National Academy of Sciences of the United States of America·Xi Chen, Francis Alonzo
Jun 11, 2019·Mediators of Inflammation·Christian BehmOleh Andrukhov
Sep 29, 2020·Journal of Bone and Joint Infection·Stephanie L Grach, Aaron J Tande

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