PMID: 2116174Jul 16, 1990Paper

Lipoproteins secreted by cultured rat hepatocytes contain the antioxidant 1-alk-1-enyl-2-acylglycerophosphoethanolamine

Biochimica Et Biophysica Acta
J E Vance

Abstract

Monolayer cultures of rat hepatocytes have been examined for their ability to secrete ethanolamine plasmalogen as a component of nascent lipoproteins. In culture medium from these cells, ethanolamine plasmalogen comprises approx. 20-30% of total ethanolamine glycerophospholipids when measured either as phospholipid mass or by the incorporation of [1-3H]ethanolamine. An approximately equal distribution of the plasmalogen was found throughout all lipoprotein density fractions. The content of plasmalogen in whole rat serum, was 36% of total ethanolamine glycerophospholipids. In contrast, in rat liver and cultured hepatocytes the amount of ethanolamine plasmalogen was 5-fold lower than in serum or culture medium (approx. 5% of total ethanolamine phospholipids). Normal human plasma also contains ethanolamine plasmalogen in relatively large amounts (approx. 50% of total ethanolamine phospholipids). Thus, a major function of plasmalogen biosynthetic enzymes in liver may be the provision of ethanolamine plasmalogen for secretion into lipoproteins. Previous studies (e.g., Zoeller, R.A. et al. (1988) J. Biol. Chem. 263, 11590-11596) have suggested that ethanolamine plasmalogen may function as an antioxidant for the protection of lipid an...Continue Reading

References

Apr 14, 1989·Biochemical and Biophysical Research Communications·R L Hamilton, P E Fielding
Jun 1, 1988·Trends in Biochemical Sciences·H Goldfine, T A Langworthy
Jan 1, 1986·Methods in Enzymology·V N Schumaker, D L Puppione
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S ParthasarathyD Steinberg
May 1, 1968·European Journal of Biochemistry·G A Arvidson
Mar 1, 1982·The Journal of Cell Biology·K E Howell, G E Palade
Jan 17, 1984·Biochimica Et Biophysica Acta·D E VanceD Steinberg
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·U P SteinbrecherD Steinberg
Mar 1, 1966·Lipids·J H WilliamsR F Witter

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Citations

Jul 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·V M MannM J Connock
Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Sep 24, 2013·Analytical Biochemistry·Wen-Yi WangDavid A Ford
May 17, 2005·Brain Research. Molecular Brain Research·Agnès AndréJean-Michel Chardigny
Oct 31, 1998·Biochimica Et Biophysica Acta·T C Lee
Dec 3, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·K KikuchiK Takama
Jul 5, 2011·Chemistry and Physics of Lipids·Stefan Wallner, Gerd Schmitz
Dec 19, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Carolyn J AlbertDavid A Ford
Jul 1, 1996·Metabolism: Clinical and Experimental·K MimuraJ M Johnston
Jul 25, 2006·Chemistry and Physics of Lipids·Maria C MessnerDavid A Ford
Feb 11, 2014·Cell Metabolism·Irfan J Lodhi, Clay F Semenkovich
Jun 21, 2012·Free Radical Biology & Medicine·Bradley K WackerDavid A Ford
Mar 3, 2007·Journal of Atherosclerosis and Thrombosis·Ryouta MaebaTamio Teramoto
May 26, 2012·Biochimica Et Biophysica Acta·Nancy E Braverman, Ann B Moser
Jan 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M H Johnson, M H Nasr-Esfahani
Nov 30, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Mika, T Sledzinski
Jan 3, 2019·American Journal of Physiology. Endocrinology and Metabolism·Meghan L RuebelAline Andres
Sep 24, 2010·The Biochemical Journal·Shin-ya MoritaShuji Kitagawa
Aug 3, 2020·Journal of Pediatric Gastroenterology and Nutrition·Laura G DraijerBart G P Koot
Aug 23, 2019·Life Science Alliance·Tomohiro KimuraRichard M Epand
Sep 22, 2020·World Journal of Hepatology·Sofia KartsoliDimitrios K Christodoulou
Sep 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Laura G DraijerBart G P Koot
Sep 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marisa PfohlAngela L Slitt
Apr 25, 2021·Journal of Lipid Research·Larry D SpearsClay F Semenkovich
Jun 19, 1995·Chemistry and Physics of Lipids·R Felde, G Spiteller

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