PMID: 589698Nov 1, 1977

Liposolubility as an aspect of nitrosamine carcinogenicity: quantitative correlations and qualitative observations

Chemico-biological Interactions
G M SingerW Lijinsky


Carcinogenicity data for a number of nitrosamines have been examined for possible structure-activity correlations with liposolubility by the method of Hansch. Correlations were found in two cases which support a previous mechanistic suggestion and which also suggest a possible difference between the action of nitrosopiperidines and dinitrosopiperazines in inducing olfactory carcinomas. No correlations were found for non-cyclic nitrosamines.


Apr 1, 1975·Journal of Pharmaceutical Sciences·R N SmithM M Ames
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·W Lijinsky, H W Taylor
Jan 1, 1972·Journal of Pharmaceutical Sciences·C Hansch, W J Dunn
Jan 1, 1973·Journal of Pharmaceutical Sciences·C Hansch, J M Clayton


Jan 1, 1986·Environmental Mutagenesis·M R FriersonH S Rosenkranz

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Neoplasms, Experimental
Structure-Activity Relationship

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