Liposomal amphotericin B (Fungisome) for the treatment of cryptococcal meningitis in HIV/AIDS patients in India: a multicentric, randomized controlled trial

Journal of Postgraduate Medicine
M P JadhavR Digumarathi

Abstract

There is need to investigate the use of liposomal amphotericin B in cryptococcal meningitis in India. To compare the efficacy, safety, duration of treatment and cost of two doses of liposomal amphotericin B (Amp B) (Fungisome) in cryptococcal meningitis in HIV/AIDS patients. Prospective, randomized, multicenter study in tertiary care hospitals across India. Adult patients with culture-proven cryptococcal meningitis with HIV/AIDS were randomized to receive either 1 (Group A) or 3 mg/kg/day of Fungisome (Group B). Clinical efficacy and tolerability, laboratory evaluations and mycological response were assessed daily, twice weekly and weekly respectively. The patients were assessed at four and eight-week follow-up. We calculated average and standard deviation for the various parameters. The time to show clinical response was 13.66 days (1 mg) and 9.55 days (3 mg). In Group B (n=6 complete response), 50% patients responded within one week by microbial conversion, 83% in two weeks and 100% in three weeks. Patients with 1 mg dose (n=4 complete response), none showed microbial conversion within one week, 75% responded in two weeks, whereas one patient took four weeks. The average duration of treatment was 36.5+/-14.4 and 26.5+/-5.89 (...Continue Reading

Citations

Jun 6, 2013·The Lancet Infectious Diseases·Angela LoyseTihana Bicanic
Sep 21, 2013·ISRN AIDS·Spinello Antinori
Apr 25, 2014·The Lancet Infectious Diseases·Angela LoyseUNKNOWN all authors
Apr 25, 2014·The Lancet Infectious Diseases·Manoj P Jadhav, Nilima A Kshirsagar
Jan 27, 2018·Journal of Fungi·Jamal Wadi, David W Denning
Jul 26, 2018·The Cochrane Database of Systematic Reviews·Mark W TenfordeNathan Ford
Nov 14, 2012·Current Opinion in Infectious Diseases·Abeer H A Mohamed-AhmedSimon L Croft

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