Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis.

Indian Journal of Pharmacology
Ramadoss RamuRajesh Satyapal Taneja

Abstract

Amphotericin B (AmB) is a polyene antifungal agent used widely for systemic fungal infections. Infusion-related side effects, nephrotoxicity, and dyselectrolytemia are well-known adverse effects with the use of this drug. Liposomal preparation of AmB has less adverse events. However, ototoxicity due to AmB is scarcely mentioned in the literature. We report a case of disseminated histoplasmosis who was treated with liposomal amphotericin B (LAmB) and developed hearing loss during the treatment, which recovered after discontinuing the drug. This is a rare adverse effect of LAmB and reported only once from India, to the best of our knowledge.

References

Jun 22, 2007·The New England Journal of Medicine·Shyam SundarSujit K Bhattacharya
Oct 20, 2009·Revista iberoamericana de micología·Rafael Laniado-Laborín, Maria Noemí Cabrales-Vargas
Dec 22, 2016·Clinical Pharmacology and Therapeutics·C Lanvers-KaminskyG Ciarimboli

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