Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Adriana E BulboacăGabriela Dogaru

Abstract

Curcumin (CC) is known to have anti-inflammatory and anti-oxidative properties and has already been tested for its efficiency in different diseases including diabetes mellitus (DM). New formulations and route administration were designed to obtain products with higher bioavailability. Our study aimed to test the effect of intraperitoneal (i.p.) administration of liposomal curcumin (lCC) as pre-treatment in streptozotocin(STZ)-induced DM in rats on oxidative stress, liver, and pancreatic functional parameters. Forty-two Wistar-Bratislava rats were randomly divided into six groups (seven animals/group): control (no diabetes), control-STZ (STZ-induced DM -60 mg/100g body weight a single dose intraperitoneal administration, and no CC pre-treatment), two groups with DM and CC pre-treatment (1mg/100g bw-STZ + CC1, 2 mg/100g bw-STZ + CC2), and two groups with DM and lCC pre-treatment (1 mg/100g bw-STZ + lCC1, 2 mg/100g bw-STZ + lCC1). Intraperitoneal administration of Curcumin in diabetic rats showed a significant reduction of nitric oxide, malondialdehyde, total oxidative stress, and catalase for both evaluated formulations (CC and lCC) compared to control group (p < 0.005), with higher efficacy of lCC formulation compared to CC solu...Continue Reading

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Citations

Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Csaba HegedűsRita Kiss
Sep 7, 2019·Journal of Food Biochemistry·Rana EssaAhmed Abdellatif
Jun 20, 2020·Archives of Pharmacal Research·Sara OliveiraPaulo Matafome
Jun 18, 2019·Oxidative Medicine and Cellular Longevity·Paul-Mihai BoarescuSorana D Bolboacă
Aug 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paul-Mihai BoarescuSorana D Bolboacă
Jan 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yanan WangZhiyu He

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