Liposomal hypocrellin B as a potential photosensitizer for age-related macular degeneration: pharmacokinetics, photodynamic efficacy, and skin phototoxicity in vivo

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Tinghui LiYing Gu

Abstract

Photodynamic therapy (PDT) has been successfully implemented as a treatment for wet age-related macular degeneration (AMD), but very few photosensitizers have been developed for clinical use. Herein, we describe a novel formulation of liposomal hypocrellin B (LHB) that was prepared by high-pressure homogenization. The encapsulation efficiency and PDT efficacy in vitro of this new preparation were found to remain nearly constant over 1 year. Moreover, LHB is rapidly cleared from the blood, with a half-life of 2.319 ± 0.462 h and a very low serum concentration at 24 h after injection. Testing in a rat model of choroidal neovascularization (CNV) showed that leakage of blood vessels in CNV lesions was significantly reduced when LHB PDT was given at a dose of 1 mg kg(-1) along with yellow laser irradiation; the damage to the collateral retina and the retinal pigment epithelium was minimal. Skin phototoxicity assays showed that only two of the 200 mice given a 4 mg per kg dose of LHB experienced an inflammatory reaction in the auricle irradiated at 24 h after dosing. These data collectively indicate that LHB may be a safe and effective photosensitizer for vascular-targeted PDT of AMD.

References

Mar 1, 1980·The Journal of Investigative Dermatology·S H BarskyJ M Noe
Mar 1, 1994·Journal of Leukocyte Biology·C SunderkötterC Sorg
Jan 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·S T WolfordB Kelly
Mar 1, 1994·Photochemistry and Photobiology·B AvelineR W Redmond
Apr 17, 1999·Archives of Ophthalmology·N M Bressler
Jan 12, 2001·Journal of Photochemistry and Photobiology. B, Biology·S StolikL Anasagasti
May 23, 2001·Photochemistry and Photobiology·C YuT Shen
May 15, 2003·Survey of Ophthalmology·Jayakrishna AmbatiAnthony P Adamis
Dec 19, 2003·Chemical Communications : Chem Comm·Sheng Qin XiaBao Wen Zhang
Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
Apr 3, 2004·American Journal of Ophthalmology·Jennifer J ArnoldUNKNOWN Verteporfin in Photodynamic Therapy Study Group
May 17, 2005·Journal of Photochemistry and Photobiology. B, Biology·Mehmet D BilginY Murat Elçin
Dec 31, 2005·Investigative Ophthalmology & Visual Science·Radouil TzekovJames Burke
Oct 6, 2006·The New England Journal of Medicine·David M BrownUNKNOWN ANCHOR Study Group
Nov 25, 2006·Ophthalmology·Christopher Kai-shun LeungDennis Shun-chiu Lam
Mar 29, 2007·The Journal of Physical Chemistry. B·Zhanghua ZengBaowen Zhang
Dec 21, 2007·Dermatologic Therapy·Bruce KatzJessie S Cheung
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Marianne BerdugoFrancine Behar-Cohen
Apr 4, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Noémie ThomasMuriel Barberi-Heyob
Aug 14, 2008·Medical Physics·Timothy C Zhu, Jarod C Finlay
Nov 4, 2008·Journal of Photochemistry and Photobiology. B, Biology·Bibbin T PaulRamachandran Murugesan
Nov 26, 2008·Lancet·Hanna R ColemanEmily Y Chew
May 9, 2009·Survey of Ophthalmology·José TuñónJesús Egido
Jan 29, 2010·Mini Reviews in Medicinal Chemistry·Jingquan ZhaoYing Gu
Nov 3, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jane Huan-Jing Lock, Kenneth Choong Sian Fong
Feb 25, 2011·The New England Journal of Medicine·Deborah A Martin, Sanjaya Senanayake
May 4, 2011·International Journal of Toxicology·Zhixiang ZhouRugang Zhong
Jul 21, 2012·American Journal of Ophthalmology·David J BrowningMichael W Stewart
Feb 1, 2014·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Monica VaranoMariacristina Parravano

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Citations

May 30, 2015·Journal of Agricultural and Food Chemistry·Eva Tavčar Benković, Samo Kreft
May 20, 2016·Drug Delivery and Translational Research·Joanne D DuBen J Boyd
Apr 23, 2010·Journal of Photochemistry and Photobiology. B, Biology·Ivica KoprivaLina Mirić
Feb 11, 2016·The Biochemical Journal·Heidi Abrahamse, Michael R Hamblin
Oct 22, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Woodvine OtienoYanhong Ji
Nov 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Krzysztof SztanderaBarbara Klajnert-Maculewicz
Mar 12, 2021·Expert Opinion on Drug Delivery·Puneet Sharma, Sachin Mittal
Nov 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aira Sarkar, Sathish Dyawanapelly
Mar 24, 2021·International Journal of Pharmaceutics·Sunil Kumar DubeyPrashant Kesharwani
Sep 30, 2020·Journal of Medicinal Chemistry·João C S SimõesGeorge Loudos

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