Liposomal treatment of xerostomia, odor, and taste abnormalities in patients with head and neck cancer

Head & Neck
Clemens HeiserAndreas Knopf

Abstract

Smell and taste disorders, sicca symptoms, can be detected in patients with head and neck cancer. The purpose of this study was to assess the utility of local liposomal application in the treatment of patients with head and neck cancers. Ninety-eight patients with head and neck cancer were included in this study. The groups were defined as: group 1 = only surgery; group 2 = surgery + adjuvant radiochemotherapy; and group 3 = primarily radiochemotherapy. All patients had finished cancer treatment and received liposomal sprays for the nose and mouth for 2 months (LipoNasal, LipoSaliva; Optima Pharmaceutical GmbH, Germany) and suffered from taste and smell disorders. We performed tests with "Sniffin' Sticks," "Taste Strips," and a xerostomia questionnaire before and after treatment. After application of liposomes, patients demonstrated a statistically significant increase in smell and taste, and reduced xerostomia. Our results demonstrate that using nonpharmaceutical liposomal sprays improve smell, taste, and symptoms of xerostomia in patients with head and neck cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1232-E1237, 2016.

References

Jul 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·J GuggenheimerJ Schmutz
Nov 1, 1975·Cancer·W D DeWys, K Walters
Aug 1, 1988·Archives of Otolaryngology--head & Neck Surgery·D OphirR Gross-Isseroff
Jul 1, 1982·The American Journal of Clinical Nutrition·A S TrantH O Douglass
Jun 25, 1994·BMJ : British Medical Journal·J Austoker
Nov 1, 1993·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S Holmes
Aug 1, 1993·The Clinical Investigator·M H Schmid, H C Korting
Mar 30, 1999·The Proceedings of the Nutrition Society·H I DavidsonR A Richardson
Jun 9, 2000·The Journal of Laryngology and Otology·R H SayedT H Saleem
Jun 27, 2000·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G KobalT Hummel
Oct 18, 2001·Acta Oto-laryngologica·M WolfensbergerA Welge-Lüssen
Jan 5, 2002·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·T B ComeauC Migas
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Annelies MaesWalter Van den Bogaert
Jul 10, 2002·American Journal of Otolaryngology·Wai-kuen HoJonathan S T Sham
Jun 5, 2003·Physiology & Behavior·Liqiang ZhaoBeverly J Tepper
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A VissinkR P Coppes
Aug 16, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·N SarhillL Rybicki
Oct 23, 2004·Klinische Monatsblätter für Augenheilkunde·S LeeD Dausch
Sep 1, 2005·The Veterinary Clinics of North America. Small Animal Practice·Walter C Renberg
Jan 27, 2006·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Paula Ravasco
Apr 19, 2006·Head & Neck·Hideomi YamashitaKuni Ohtomo
Aug 5, 2006·Cancer Treatment Reviews·Maria Grazia Ruo Redda, Simona Allis
Oct 16, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Veit J ErpenbeckJens M Hohlfeld
Sep 16, 2009·Rheumatology·Usama F KamelRhiannon Whitaker
Jul 16, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M BöhmR Mösges
Aug 15, 2013·Rhinology·A BramersonM Bende

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Citations

Nov 28, 2018·Current Drug Metabolism·Pal PatelAshutosh Kumar
Jul 10, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Woo J ChiMark S Chambers

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