Liposome Based Intravesical Therapy Targeting Nerve Growth Factor Ameliorates Bladder Hypersensitivity in Rats with Experimental Colitis

The Journal of Urology
N KawamoritaN Yoshimura

Abstract

Pelvic organ cross sensitization is considered to contribute to overlapping symptoms in chronic pelvic pain syndrome. Nerve growth factor over expression in the bladder is reportedly involved in the symptom development of bladder pain syndrome/interstitial cystitis. We examined whether a reduction of over expressed nerve growth factor in the bladder by intravesical treatment with liposome and oligonucleotide conjugates would ameliorate bladder hypersensitivity in a rat colitis model. Adult female rats were divided into 1) a control group, 2) a colitis-oligonucleotide group with intracolonic TNBS (2,4,6-trinitrobenzene sulfonic acid) enema and intravesical liposome-oligonucleotide treatments, 2) a colitis-saline group with intracolonic TNBS and intravesical saline treatments, 4) a sham oligonucleotide group with intravesical liposome-oligonucleotide treatment without colitis and 5) a sham-saline group with intravesical saline treatment without colitis. Liposomes conjugated with nerve growth factor antisense oligonucleotide or saline solution were instilled in the bladder and 24 hours later colitis was induced by TNBS enema. Effects of nerve growth factor antisense treatment were evaluated by pain behavior, cystometry, molecular ...Continue Reading

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Citations

Mar 5, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Pradeep TyagiNaoki Yoshimura
Aug 4, 2018·Expert Opinion on Pharmacotherapy·Athanasios E Dellis, Athanasios G Papatsoris
Jan 20, 2018·Neurourology and Urodynamics·Tsuyoshi MajimaMomokazu Gotoh
Nov 18, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Luke Grundy, Stuart M Brierley
Jan 9, 2019·Frontiers in Neuroscience·Luke GrundyStuart M Brierley
Nov 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhijun LinMingqiang Li

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