Liposome-Coated Iron Fumarate Metal-Organic Framework Nanoparticles for Combination Therapy

Nanomaterials
Bernhard IllesHanna Engelke

Abstract

One of the main problems for effective treatment of cancer is resistances, which often require combination therapy-for effective treatment. While there are already some potential drug carriers-e.g., liposomes, available for treatment-the effective loading and retention of the desired drug ratio can be challenging. To address this challenge, we propose a new type of drug carrier: liposome-coated metal-organic framework (MOF) nanoparticles. They combine the advantages of liposomes with an easy and efficient loading process. In this work, we present the successful synthesis of liposome-coated MOF nanoparticles via the fusion method. The resulting particles, once loaded, show no premature leakage and an efficient release. Their successful loading with both single and multiple drugs at the same time makes them an interesting candidate for use in combination therapy.

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Citations

Jun 5, 2018·Advanced Materials·Shunzhi WangChad A Mirkin
Jun 8, 2018·Advanced Materials·Teresa Simon-YarzaChristian Serre
Mar 25, 2018·Chemistry : a European Journal·Jean Felix MukerabigwiKazunori Kataoka
May 26, 2020·Angewandte Chemie·Frederik HaaseStefan Wuttke
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tahir RasheedHafiz M N Iqbal
Jan 26, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Wei Chen, Chunsheng Wu
Jan 18, 2020·Angewandte Chemie·Isabel Abánades LázaroRoss S Forgan
Feb 20, 2021·ACS Applied Materials & Interfaces·Xianbin LiuMeiling Zhou
Jan 27, 2021·ACS Nano·Joshua SeabergPriyabrata Mukherjee
Dec 24, 2019·Seminars in Cancer Biology·Mohammed Razeeth Shait MohammedMohammad Imran Khan
Feb 25, 2021·International Journal of Biological Macromolecules·Melappa GovindappaArivalagan Pugazhendhi
Mar 10, 2021·Angewandte Chemie·Peng GaoBo Tang
Apr 9, 2021·ChemSusChem·Gabriel I Tovar JimenezRoberto Fernández de Luis

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Methods Mentioned

BETA
fluorescence

Software Mentioned

Perkin UVWinLab
Felix32
Zeiss
Zen
Excel
Origin

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