Liposome Crosslinked Polyacrylamide/DNA Hydrogel: a Smart Controlled-Release System for Small Molecular Payloads

Small
Danya LyuWeiwei Guo

Abstract

A novel stimuli-responsive hydrogel system with liposomes serving as both noncovalent crosslinkers and functional small molecules carriers for controlled-release is developed. Liposomes can crosslink polyacrylamide copolymers functionalized with cholesterol-modified DNA motifs to yield a DNA hydrogel system, due to the hydrophobic interaction between cholesteryl groups and the lipid bilayer of liposomes. Functional information encoded DNA motifs on the polymer backbones endow the hydrogel with programmable smart responsive properties. In a model system, the hydrogel exhibits stimuli-responsive gel-to-sol transformation triggered by the opening of DNA motifs upon the presence of a restriction endonuclease enzyme, EcoR I, or temperature change, realizing the controlled-release of liposomes which are highly efficient carriers of active small molecules payloads. Two active molecules, 1,1-dioctadecyl-3,3,3,3-tetramethylindodicarbocyanine perchlorate (DiIC18(5)) and calcein, are chosen as the hydrophobic and hydrophilic model payloads, respectively, to address the feasibility of the releasing strategy. Moreover, the hydrogel exhibits injectable property as well as self-recovery behaviors.

References

Feb 1, 1995·Current Opinion in Structural Biology·A K Aggarwal
Jan 5, 2002·Advanced Drug Delivery Reviews·Allan S Hoffman
Sep 26, 2006·Nature Materials·Soong Ho UmDan Luo
May 1, 2008·Journal of the American Chemical Society·Huanghao YangWeihong Tan
Sep 10, 2009·Angewandte Chemie·Enjun ChengDongsheng Liu
Oct 13, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pallab PradhanChristian Plank
Sep 22, 2010·Colloids and Surfaces. B, Biointerfaces·Zhi RaoTetsushi Taguchi
Nov 17, 2010·ACS Applied Materials & Interfaces·Ajfan BaeissaJuewen Liu
Oct 6, 2012·Advanced Drug Delivery Reviews·Theresa M Allen, Pieter R Cullis
Oct 18, 2012·The Analyst·Qingtao Liu, Ben J Boyd
Jan 24, 2013·Journal of the American Chemical Society·Ling YanChaoyong James Yang
Jan 29, 2014·Current Opinion in Biotechnology·Seyed-Fakhreddin Torabi, Yi Lu
Mar 20, 2014·Molecular BioSystems·Lei YanHerman O Sintim
Apr 3, 2014·Advances in Colloid and Interface Science·D GräbnerJ Schmidt
Jun 3, 2014·Accounts of Chemical Research·Dayong YangDan Luo
Jun 5, 2014·Annual Review of Analytical Chemistry·Xiangling XiongWeihong Tan
Aug 8, 2014·Angewandte Chemie·Weiwei GuoItamar Willner
Oct 24, 2014·Analytical Chemistry·Yishun HuangChaoyong James Yang
Nov 8, 2014·Advanced Materials·Weiwei GuoItamar Willner
Jan 14, 2016·Chemical Society Reviews·Juan LiWeihong Tan
May 14, 2016·Journal of Microencapsulation·Wei ZongXiaojun Han
May 30, 2016·Trends in Biochemical Sciences·Scott K Silverman
Oct 21, 2016·Journal of Microencapsulation·Xunan ZhangXiaojun Han
Feb 12, 2017·Accounts of Chemical Research·Dong WangDan Luo
Mar 2, 2017·Accounts of Chemical Research·Jason S KahnItamar Willner
Mar 17, 2017·Accounts of Chemical Research·Yu ShaoDongsheng Liu
Jun 10, 2017·Chemical Reviews·Wenhu ZhouJuewen Liu
Jul 21, 2017·ACS Nano·Stephanie Rietwyk, Dan Peer
Aug 2, 2017·Journal of the American Chemical Society·Wei MaChuanlai Xu
May 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongmei BiXiaojun Han
Aug 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Koki Kamiya, Shoji Takeuchi

❮ Previous
Next ❯

Citations

Mar 13, 2019·Annual Review of Biomedical Engineering·Barry A Badeau, Cole A DeForest
Aug 6, 2019·Advanced Materials·Fengyun LiWeiwei Guo
Feb 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liping ZhouYongqiang Wen
Mar 9, 2020·Topics in Current Chemistry·Jie ChenLihua Wang
Jan 29, 2019·Current Topics in Medicinal Chemistry·Yanan LiFeifei An
Sep 11, 2020·Nature Communications·Feng WuJinyao Liu
Jul 28, 2020·Advanced Drug Delivery Reviews·Fangli MoWeihong Tan
Nov 19, 2019·Biomacromolecules·Stefanie L BakerKrzysztof Matyjaszewski
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuel Gomez-FloritManuela E Gomes
Feb 19, 2021·Expert Opinion on Drug Delivery·Dmitrii S LinnikAlexander S Timin
Feb 23, 2021·Frontiers in Chemistry·Yanyu Zhang, Yishun Huang
Dec 18, 2019·Current Opinion in Chemical Engineering·Luisa L PalmeseKristi L Kiick
Apr 29, 2021·Macromolecular Bioscience·Wenlin ChuJianshu Li
Jun 1, 2021·Drug Discovery Today·Antonia I AntoniouSara Pellegrino
Jun 22, 2021·ACS Pharmacology & Translational Science·Nour AlSawaftahGhaleb A Husseini
Jun 22, 2021·Frontiers in Bioengineering and Biotechnology·Xueting JianYang Liu
Sep 29, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yuqing LiJuewen Liu
Nov 24, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tongmeng JiangChuanbin Mao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.