Liposome-encapsulated hemoglobin accelerates skin wound healing in mice

Artificial Organs
Tsuyoshi FukuiRica Tanaka

Abstract

Effects of liposome-encapsulated hemoglobin with high O₂ affinity (m-LEH, P₅₀O₂ = 17 mm Hg) on skin wound healing in mice were examined. Two full-thickness dorsal wounds 6 mm in diameter encompassed by silicone stents were created in Balb/c mice. Two days later (day 2), the animals randomly received intravenous m-LEH (2 mL/kg, n = 12), homologous blood transfusion (red blood cell [RBC], n = 11), or saline (n = 12). The same treatment was repeated 4 days after wounding (day 4), and the sizes of the skin defects and ulcers were monitored on days 0, 2, 4, and 7, when all animals were euthanized for morphological studies. While the size of the skin defect in relation to the stent ring remained the same in all groups, the size of the ulcer compared with the skin defect (or silicone stent) became significantly reduced on days 4 and 7 in mice treated with m-LEH (46 ± 10% of pretreatment size, P < 0.01) compared with mice treated with RBC transfusion (73 ± 6%) or saline (76 ± 7%). m-LEH treatment significantly accelerated granulation, increased epithelial thickness, suppressed early granulocyte infiltration, and increased Ki67 expression in accordance with the ulcer size reduction, while there was no difference in surface blood flow or...Continue Reading

References

Jun 26, 2001·The Journal of Surgical Research·R MandaiS Nosaka
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Oct 29, 2004·The American Journal of Pathology·Xenia BorueDiane S Krause
Jun 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ahmad Y SheikhThomas K Hunt
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Oct 31, 2008·Plastic and Reconstructive Surgery·Clarence D LinStephen M Warren
Jan 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chandan K Sen
Jan 31, 2009·Artificial Organs·Akira T Kawaguchi
Nov 17, 2009·The Journal of Pharmacology and Experimental Therapeutics·Akira T KawaguchiHideo Tsukada
Dec 17, 2011·Artificial Organs·Hitoshi IkegawaHisashi Sugimoto

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Citations

Feb 22, 2012·Artificial Organs·Akira T Kawaguchi
Aug 21, 2015·Expert Opinion on Drug Delivery·Lalduhsanga Pachuau
Jun 14, 2014·Artificial Organs·Akira T KawaguchiHiroyasu Makuuchi
Mar 6, 2013·Artificial Organs·Paul S Malchesky
Aug 27, 2014·Artificial Organs·Akira T Kawaguchi
Jul 30, 2014·Artificial Organs·Chieko MurayamaYasukazu Nagato
Aug 22, 2015·Nanomedicine·Irina KalashnikovaSudipta Seal
Mar 23, 2017·Artificial Organs·Tsuyoshi FukuiRica Tanaka
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·Shigeru MatsumotoHiroshi Mizuno
Apr 14, 2018·Frontiers in Microbiology·Sanjay ChhibberSandeep Kaur

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