PMID: 8586972Nov 15, 1995Paper

Liposome-encapsulated silver sulfadiazine (SSD) for the topical treatment of infected burns: thermodynamics of drug encapsulation and kinetics of drug release

Journal of Inorganic Biochemistry
A Lichtenstein, R Margalit

Abstract

Liposomes encapsulating silver sulfadiazine (SSD), the drug of choice for topical treatment of infected burns, are investigated as an improved delivery system that could act as a locally targeted sustained-release drug depot. This communication reports the first stage of the investigation and is focused on (a) the development of spectrophotometric assays for liposome-encapsulated and for free (aqueous soluble) and SSD, (b) on evaluation of the efficiency of encapsulation and kinetics of drug release. DMSO containing 140 mM NH3 was found to be the best solvent for dissolution of the liposomes and for determination of their SSD content. Peak absorption of liposome-originating SSD in this solvent is at 263 nm with em values of 23 x 10(3)-26 x 10(3). Peak absorption of SSD in aqueous solutions is at 254 nm with em magnitudes varying from 2 x 10(3) to 23 x 10(3), depending on the electrolytic composition of the system. Kinetic studies of drug release and separations by centrifugation and by gel-exclusion chromatography all indicate that the SSD in the liposomal system is distributed among three states: encapsulated, soluble unencapsulated, and stable (unencapsulated) aggregates that reside in the aqueous phase in which the liposomes...Continue Reading

Citations

Jul 2, 2003·Journal of Biochemical and Biophysical Methods·Cécile Grabielle-MadelmontMichel Ollivon
Sep 30, 2014·Journal of Microencapsulation·Sanket S DharashivkarAshok N Saoji
Apr 14, 2011·International Wound Journal·Zelihagül DeğimCandan Özoğul
Oct 17, 2007·Journal of Biomedical Materials Research. Part a·Ceren AlemdaroğluAhmet Nacar
Dec 13, 2006·Journal of Liposome Research·Waraporn SuwakulNontima Vardhanabhuti
Oct 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ágnes SzegediPavletta Shestakova
Mar 6, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·P LundahlE Greijer
May 1, 1997·Journal of Pharmaceutical Sciences·I Schumacher, R Margalit

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